ID   A0A448YNQ7_BRENA        Unreviewed;      1048 AA.
AC   A0A448YNQ7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE            EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN   ORFNames=BRENAR_LOCUS3247 {ECO:0000313|EMBL:VEU22516.1};
OS   Brettanomyces naardenensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Brettanomyces.
OX   NCBI_TaxID=13370 {ECO:0000313|EMBL:VEU22516.1, ECO:0000313|Proteomes:UP000290900};
RN   [1] {ECO:0000313|EMBL:VEU22516.1, ECO:0000313|Proteomes:UP000290900}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Tiukova I., Dainat J.;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the synaptojanin family.
CC       {ECO:0000256|ARBA:ARBA00008943}.
CC   -!- SIMILARITY: In the central section; belongs to the inositol 1,4,5-
CC       trisphosphate 5-phosphatase family. {ECO:0000256|ARBA:ARBA00009678}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CAACVR010000023; VEU22516.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A448YNQ7; -.
DR   STRING; 13370.A0A448YNQ7; -.
DR   InParanoid; A0A448YNQ7; -.
DR   Proteomes; UP000290900; Unassembled WGS sequence.
DR   GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR046985; IP5.
DR   InterPro; IPR000300; IPPc.
DR   InterPro; IPR002013; SAC_dom.
DR   PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR   PANTHER; PTHR11200:SF257; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR   Pfam; PF02383; Syja_N; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50275; SAC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000290900}.
FT   DOMAIN          78..428
FT                   /note="SAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50275"
FT   REGION          851..986
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1021..1048
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..876
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..892
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..907
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        919..946
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        955..986
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1021..1036
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1048 AA;  117488 MW;  80AE81BDC7B55676 CRC64;
     MGTDVFLCVI TGRIEVASPM AGERINRIYD VEFPCLTKDV WDFLDINGNG YPVTDSDSDS
     SAPGGFTPRI EQNPCYELRK ILSDGSFYYS TDFDLTSTLQ GRGIRKSQQQ LSVDRYHMDY
     MWNAFMMKEI IHFRNNLDDE PKQALDSNRF LTTVIRGFAE SVKTTVGGKN ARLTIVSKQS
     WKRTGTRFNV RGIDDDGNVA NFVETECILN DGLHAFAYTQ IRGSIPLFWE QDTALVSPKV
     QVTRSFDASQ PVFEKHFANL NGKYGPVHIV NLLSKTKSSE VTLSRAYKEH FRALKEKTPD
     SLYFTDFDFH QETSKTYADA DRVLRPLKPS LQDFGYFCYD LKENETIMEQ QGVFRTNCLD
     CLDRTNVVQQ VISRAALDEY MADFNMSKDD YSSPYVSNTG DVIESPVHAK HSVLWADHGD
     QISQIYTGTN ALKSSFSRSG KMGFAGALSD ATKSLSRIYI NNFVDKGKQV VIDTLLGKNS
     NQMPVLIFDP VTEYLTDRLH QAEPEFTTFR DISIFAGTFN LSGASQGTSL AEWLFPEQLG
     TSYPDIYLVG FQEVIELNAS SILKNDGSAG QYWKNAVQKQ LDQGPGPHYV LLRSEYMSSI
     LLLLFVKEDE MTNVTQVEGK SKKTGLGGMT ANKGSVAIRF NYGSTSFCLF NSHLASGVTN
     TEERFNDFLT CWNGIRFSRN RLIKHHDNVV WTGDLNYRVS LPNEDTRALI EQGMLAKLLS
     YDQLGYEMKR HPELQGFTEL PITFPPTYKF DKLSDNYDTS EKQRVPSWTD RIMFQGDEIS
     QLYYQRAAGI RFSDHRPVFG SFSARVKLVN SERKHSLTRK FLQEYKSTAA KSSGSVLIEL
     NVYSGDEDSF ASSTWSSTNS APTLIDLSAP SEDSERQSSE PPPPIPRRLP RRVPPPFDAR
     EVSEMVRNEP ELSGISSPIP MTDVASAGSS TSSTPISYSV MRPTRSRAGT SLPPLPPRES
     TTTATLSTAN RPVPPVPRKS TSSSLVPPVL ASNKEAHKVP PLVPVKPKSL NVFYSELETD
     TANEASQAVQ QNSPPPNQWM PMAPTKRR
//