ID   A0A448YNT0_BRENA        Unreviewed;       447 AA.
AC   A0A448YNT0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=DEKNAAC103607 {ECO:0000313|EMBL:VEU22594.1};
GN   ORFNames=BRENAR_LOCUS3325 {ECO:0000313|EMBL:VEU22594.1};
OS   Brettanomyces naardenensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Brettanomyces.
OX   NCBI_TaxID=13370 {ECO:0000313|EMBL:VEU22594.1, ECO:0000313|Proteomes:UP000290900};
RN   [1] {ECO:0000313|EMBL:VEU22594.1, ECO:0000313|Proteomes:UP000290900}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Tiukova I., Dainat J.;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CAACVR010000023; VEU22594.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A448YNT0; -.
DR   STRING; 13370.A0A448YNT0; -.
DR   InParanoid; A0A448YNT0; -.
DR   Proteomes; UP000290900; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1870.10; Domain 3, Saccharopine reductase; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032095; Sacchrp_dh-like_C.
DR   InterPro; IPR005097; Sacchrp_dh_NADP.
DR   PANTHER; PTHR11133:SF25; ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR   Pfam; PF16653; Sacchrp_dh_C; 1.
DR   Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR   SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW   Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290900}.
FT   DOMAIN          6..119
FT                   /note="Saccharopine dehydrogenase NADP binding"
FT                   /evidence="ECO:0000259|Pfam:PF03435"
FT   DOMAIN          123..440
FT                   /note="Saccharopine dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16653"
SQ   SEQUENCE   447 AA;  48960 MW;  2D636C67F6262854 CRC64;
     MATKKVLLLG SGFVAQPTID ILSKEPGVEL TVGCRHLESA KKLAQPGNKT VAVDASNQEE
     LDKLVAQYDL AISLIPYIYH VNVVKAGIKG HTDVVTTSYI SDAMRALEPE IKKAGIVVMN
     EIGLDPGIDH LYAVRAIHEA HAKGGKVTSF ISFCGGLPAP EDSDNPLGYK FSWSARGVLL
     ALQHTAHYYK DDKIVEVPAK DLMASAKPYL IYPGFALVSY PNRDSTTYRE LYNIPEAQNC
     IRGTLRFQGF CEFVQVLVDL GFLKDAANPI FSEPIAWKDA LSQYIGAKSN SAEDILAKVD
     SLTKYKSEED KERVHAGIKW LGLLSDTKIH PRGNALDALC ATMEDLMQFG PKERDLVVLQ
     HKFVIEYPDG KKETKTSTLI DYGIPGGYSS MARTVGIPCA VACKLVLKHS GVYAKPGLYA
     PLTPEVAEPL LEDLKNDYGI FLVEKTL
//