ID   A0A448ZMW9_9STRA        Unreviewed;      1198 AA.
AC   A0A448ZMW9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Peptidase M16 N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PSNMU_V1.4_AUG-EV-PASAV3_0104050
GN   {ECO:0000313|EMBL:VEU43382.1};
OS   Pseudo-nitzschia multistriata.
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Bacillariophyceae; Bacillariophycidae; Bacillariales; Bacillariaceae;
OC   Pseudo-nitzschia.
OX   NCBI_TaxID=183589 {ECO:0000313|EMBL:VEU43382.1, ECO:0000313|Proteomes:UP000291116};
RN   [1] {ECO:0000313|EMBL:VEU43382.1, ECO:0000313|Proteomes:UP000291116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B856 {ECO:0000313|EMBL:VEU43382.1,
RC   ECO:0000313|Proteomes:UP000291116};
RA   Ferrante I. M.;
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; CAACVS010000540; VEU43382.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A448ZMW9; -.
DR   EnsemblProtists; VEU43382; VEU43382; PSNMU_V1.4_AUG-EV-PASAV3_0104050.
DR   Proteomes; UP000291116; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291116};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          35..160
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          196..406
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          445..772
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
SQ   SEQUENCE   1198 AA;  133651 MW;  0ED59E737422DDE1 CRC64;
     MSTVKQTPLP TPLKGKADWR EYKAFRLENG VTCLAINDKE SKTTAMSCIV EVGASSDPRE
     LSGLAHFCEH MCFLGSEKYP GENQYKRYLS SHGGRSNAST SMHLTNFKFE VLADHAEKAV
     DIFSNFFVSP LFTSSGTSRE VQAVSSENSK NLTADGRRRL QILKDLADQD HYYSKFSTGN
     SETLPSDSPE KLEWLREALL AFHRRHYRPE KMTVVIAGPQ PMETLEKWVG ERYSKIKTAS
     SSSNGEIEES IAALRLNVEK LVAIAAKDAP PYAFEEAAPP YNSAFRSSLL KSNEDGDSTW
     PILLTTKPLR SMRKLNMMFP IPSDRKTPDR APSSMLSHLL GHEGVGSAFA ALQNSGLLSS
     LSSGARTRAP DFTLFQIDMG LTEKGEENWE EVANTIFAYC RMLQKKANGK NNDGNDDPEA
     VNELRRIWEE NGELHRIFFD QTSPSGAYSY APDICDSVVS YGTEACLSAG RMLHETKASF
     PLKDFTEYTE LLVPENCIVE RCSEEAYKEM EMKDKGLFPD GFGLKKERWY GVEYYLAQIE
     KNRVLEWKGL DGLSAMNNGT NVVCQSSGLH LPLPNRYIPR TLELCPDLPE EARRGQRIDK
     PIDPPSLLVN EENWKLFHRL DDRYALPKSS LQLLIRNLSL QNTKNEKGEW IHNPKSVLLS
     SFLAAIFNES MAQETYDASL AGLRWSLSIG STGIKLNCFG FSDRLPDLAL RVLSDFLSGE
     FLRDEKFFVA SRDRVIRSLG TYFESRRADA HAMYYRDSLL SSKDEGVAEK LEIAIAAEFE
     DVVKHHQTVL QDTERSVQCL FNGNVSRGEA MEFFSSAKAK IKEAYEARAQ EPLDDEAQTL
     IDPGMVERQL QQGQDIELHF SSQNVEEENG AVLCSYQSSI PSFKGETLSH PLALRSSSTI
     RLICHMMREP LFDSLRTKQQ LGYIVSSYYE IGMTSQSNEN GRVPLTTPVD FISINVLSQK
     MAPPDIADRI DEFIEDFRRS LEAMPESEIR DHADALATKL LKPTQKLLQE AGSQYSRIQH
     YGPEVFHRRK QQSVAPGAPA TVGGHEIPWD TTKALASTIR GLGREDLLET FDRMTHPSRR
     SRVVSCVYGK KFPLATGGAS AGPGRRPSPI ASVVGAMVPL WRPRPRTTPN PAIVVGSLQE
     LLSLRRRLPG FDLAGRGPPV RARGRTMAAV GLGVALLGVA AAARRERPPT APGRKEAS
//