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Database: UniProt
Entry: A0A449AVJ9_9MOLU
LinkDB: A0A449AVJ9_9MOLU
Original site: A0A449AVJ9_9MOLU 
ID   A0A449AVJ9_9MOLU        Unreviewed;       193 AA.
AC   A0A449AVJ9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN   Name=folA {ECO:0000313|EMBL:VEU70561.1};
GN   ORFNames=NCTC10194_00491 {ECO:0000313|EMBL:VEU70561.1};
OS   Mycoplasmopsis glycophila.
OC   Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX   NCBI_TaxID=171285 {ECO:0000313|EMBL:VEU70561.1, ECO:0000313|Proteomes:UP000290815};
RN   [1] {ECO:0000313|EMBL:VEU70561.1, ECO:0000313|Proteomes:UP000290815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10194 {ECO:0000313|EMBL:VEU70561.1,
RC   ECO:0000313|Proteomes:UP000290815};
RG   Pathogen Informatics;
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC       tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004903}.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
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DR   EMBL; LR215024; VEU70561.1; -; Genomic_DNA.
DR   RefSeq; WP_052353020.1; NZ_LR215024.1.
DR   AlphaFoldDB; A0A449AVJ9; -.
DR   KEGG; mgly:NCTC10194_00491; -.
DR   UniPathway; UPA00077; UER00158.
DR   Proteomes; UP000290815; Chromosome 1.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:VEU70561.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290815}.
FT   DOMAIN          1..193
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   193 AA;  23045 MW;  A74DCB113E93A693 CRC64;
     MIKMIFAATK SGVIGLDQSL PWKIKNELNY FKNYTKDASL FMGSKTLLSL PKTFQKENRQ
     IYSFATNNKE YDLLIDFYLK DEKDLVAMFE KFQNSKETLC IIGGKEIFEK YWFLADEISF
     SLIKKEYKGN VIFNSLHSSL IDPNYKLFED NEFIVYLRNL KTDPIWIWFQ NQRISSRELK
     EHFFLIKKKS FKI
//
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