ID A0A449AVJ9_9MOLU Unreviewed; 193 AA.
AC A0A449AVJ9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=folA {ECO:0000313|EMBL:VEU70561.1};
GN ORFNames=NCTC10194_00491 {ECO:0000313|EMBL:VEU70561.1};
OS Mycoplasmopsis glycophila.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX NCBI_TaxID=171285 {ECO:0000313|EMBL:VEU70561.1, ECO:0000313|Proteomes:UP000290815};
RN [1] {ECO:0000313|EMBL:VEU70561.1, ECO:0000313|Proteomes:UP000290815}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10194 {ECO:0000313|EMBL:VEU70561.1,
RC ECO:0000313|Proteomes:UP000290815};
RG Pathogen Informatics;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|RuleBase:RU004474}.
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DR EMBL; LR215024; VEU70561.1; -; Genomic_DNA.
DR RefSeq; WP_052353020.1; NZ_LR215024.1.
DR AlphaFoldDB; A0A449AVJ9; -.
DR KEGG; mgly:NCTC10194_00491; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000290815; Chromosome 1.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:VEU70561.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290815}.
FT DOMAIN 1..193
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 193 AA; 23045 MW; A74DCB113E93A693 CRC64;
MIKMIFAATK SGVIGLDQSL PWKIKNELNY FKNYTKDASL FMGSKTLLSL PKTFQKENRQ
IYSFATNNKE YDLLIDFYLK DEKDLVAMFE KFQNSKETLC IIGGKEIFEK YWFLADEISF
SLIKKEYKGN VIFNSLHSSL IDPNYKLFED NEFIVYLRNL KTDPIWIWFQ NQRISSRELK
EHFFLIKKKS FKI
//