ID   A0A452C4U5_BALAS        Unreviewed;       735 AA.
AC   A0A452C4U5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 {ECO:0000313|RefSeq:XP_028017986.1};
GN   Name=HCN1 {ECO:0000313|RefSeq:XP_028017986.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028017986.1};
RN   [1] {ECO:0000313|RefSeq:XP_028017986.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028017986.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_028017986.1; XM_028162185.1.
DR   AlphaFoldDB; A0A452C4U5; -.
DR   STRING; 310752.A0A452C4U5; -.
DR   InParanoid; A0A452C4U5; -.
DR   OrthoDB; 74296at2759; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR   PANTHER; PTHR45689:SF3; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..735
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019363772"
FT   DOMAIN          327..433
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          500..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          651..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          692..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  82516 MW;  1ACD5A6E3B77A398 CRC64;
     MLIMMVGNLV IIPVGITFFT EQTTTPWIIF NVASDTVFLL DLIMNFRTGT VNEDSSEIIL
     DPKVIKMNYL KSWFVVDFIS SIPVDYIFLI VEKGMDSEVY KTARALRIVR FTKILSLLRL
     LRLSRLIRYI HQWEEIFHMT YDLASAVVRI FNLIGMMLLL CHWDGCLQFL VPLLQDFPPD
     CWVSLNEMVN DSWGKQYSYA LFKAMSHMLC IGYGAQAPVS MSDLWITMLS MIVGATCYAM
     FVGHATALIQ SLDSSRRQYQ EKYKQVEQYM SFHKLPADMR QKIHDYYEHR YQGKIFDEEN
     ILNELNDPLR EEIVNFNCRK LVATMPLFAN ADPNFVTAML SKLRFEVFQP GDYIIREGAV
     GKKMYFIQHG VAGVITKSSK EMKLTDGSYF GEICLLTKGR RTASVRADTY CRLYSLSVDN
     FNEVLEEYPM MRRAFETVAI DRLDRIGKKN SILLQKFQKD LNTGVFNNQE NEILKQIVKH
     DREMVQAIAP ISYPQMTALN STSSATTPTP RGRTQSPPVY TATSLSHGNL HSPSPSTQTP
     QPSAILSPCS YTTAVCSPPV QSPLATRTFH YASPTASQLS LIQQQAQQTL QTKQQNQAPQ
     TPGGSSAPKN EVHKSTQALH NTSLTREVRP LSASQPSLPH EVSTLISRPH PTVGESLASI
     PPPVTTVHGS GLQAGSRGTV PQRVTLFRQM SSGAIPPSRG VPPAPPPPAA AHQRESSSVL
     HTDPETEKPR FASNL
//