ID A0A452C4W5_BALAS Unreviewed; 641 AA.
AC A0A452C4W5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Transcriptional repressor p66-alpha isoform X7 {ECO:0000313|RefSeq:XP_028017980.1};
GN Name=GATAD2A {ECO:0000313|RefSeq:XP_028017980.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028017980.1};
RN [1] {ECO:0000313|RefSeq:XP_028017980.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028017980.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007195475.1; XM_007195413.1.
DR RefSeq; XP_028017980.1; XM_028162179.1.
DR AlphaFoldDB; A0A452C4W5; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.250.1650; -; 1.
DR InterPro; IPR040386; P66.
DR InterPro; IPR032346; P66_CC.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR13455:SF3; TRANSCRIPTIONAL REPRESSOR P66-ALPHA; 1.
DR PANTHER; PTHR13455; TRANSCRIPTIONAL REPRESSOR P66-RELATED; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF16563; P66_CC; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00094};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00094}.
FT DOMAIN 444..474
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 39..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 68993 MW; 056168EF1A1B0F64 CRC64;
MLFLCLDHLP GFLFPPWPQP VRLHLSTLAS QKFRMTEEAC RTRSQKRALD RDPAEDDVES
KKIKMERGVL ASELNADGDM RVTPEPGAGP AQGLLRGAEA MAMGRGEGQV GDGPVDMRTT
HSDMKSERRA PSPDVIVLSD NEQPASPRVN GLTEDALKET STEALMKSSP EERERMIKQL
KEELRLEEAK LVLLKKLRQS QIQKETTTQK PAGSTGSSVT TPPPLVRGTQ NIPSSKPSLQ
TSSTRMPGSV IPPPLVRGGQ QTSSKLGPQA SSQVVMPPLV RGAQQIHNIR QHSSTGPPPL
LLAPRASVPS VQIQGQRIIQ QGLIRVANVP NTSLLVNIPQ PSPASLKGTT ATSAQANSTP
TSVTSVVTSA DSPASRQAAA KLALRKQLEK TLLEIPPPKP PAPEMNFLPS AANNEFIYLV
GLEEVVQNLL ETQAGRMSAA VVLSREPYMC VQCKTDFTCR WREEKGGAIM CENCMASNQK
KALKVEHTSR LKAAFVKALQ QEQEIEQRLL QQGAAPAQAK AEPAAAPHPA LKQASSQLSR
GSATTPRGIL HTFSQSPKLQ NAASATALVS RTGRHSERAV SAGKGNATSN WKKAPLSTGG
ALAFVSPSLA VHKTSSAVDR QREYLLDMIP PRSIPQSATW K
//
