ID A0A452C4Z8_BALAS Unreviewed; 654 AA.
AC A0A452C4Z8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Thyroid peroxidase {ECO:0000313|RefSeq:XP_028018036.1};
GN Name=TPO {ECO:0000313|RefSeq:XP_028018036.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028018036.1};
RN [1] {ECO:0000313|RefSeq:XP_028018036.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028018036.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_028018036.1; XM_028162235.1.
DR AlphaFoldDB; A0A452C4Z8; -.
DR STRING; 310752.A0A452C4Z8; -.
DR InParanoid; A0A452C4Z8; -.
DR OrthoDB; 4560at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 2.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF60; THYROID PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00032; CCP; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000313|RefSeq:XP_028018036.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 630..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 565..621
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT BINDING 321
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 654 AA; 72351 MW; 79D8BC6E29D17DCB CRC64;
MGARAVLGTT LAVACAGAVF SFLLRHKDLF WGETEECRVR GIVEASKLLV DQAVYSTMRR
NLHKREIISP SQLLSFSKLP EPASRAASRA ADVMEMSVQE AMRRAHLRSA PSGPPTDVLS
EDLLKTIAHL SGCQPYMLPP RCPNTCLANK FRLITGACNN RDHPRRGAAN TALARWLPPA
YEDGISEPRG WNPRLRYNGF PLPPVREVSR QVIHVSNEAV TEDGQYSDLL MAWGQYIDHD
MAFTPQSASL AAFGGGADCQ QTCENRSPCF PIQVITLRDY VPKILGPEAF GQHVGPYRGY
DPAVDPTVSN VFSTAAFRFG HATVHPLVRR LDARFQERPG LLPLRDAFFR PWRLLEEGGV
DPIMRGLLAT PAKLQVQDQL MNAELTEGLF VLSDSGTLDL AAINLQRGRD HGLPGYNEWR
EFCGLSRLET RANLRATSSN GSVADKILDL YGHPANIDVW LGGLAERVLP GARTGPLFAC
IIGKQMRKLR DGDRFWWENQ AVFTEAQRRE LGRHSLSRVI CDNTGLSRVP RDAFRVGTWP
QEFESCDSIP GMNLGAWREA PPPEDACGFP GKVEDGDFLL CEESGKRVLV FSCRHGFQLQ
GPEQIACTRR GWDSQPPVCK DSGRLPRASM VSIVLGAVLV CGLAGLTWTV VCRW
//
