ID A0A452C5C6_BALAS Unreviewed; 870 AA.
AC A0A452C5C6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE SubName: Full=Breakpoint cluster region protein isoform X5 {ECO:0000313|RefSeq:XP_028018156.1};
GN Name=BCR {ECO:0000313|RefSeq:XP_028018156.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028018156.1};
RN [1] {ECO:0000313|RefSeq:XP_028018156.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028018156.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_028018156.1; XM_028162355.1.
DR AlphaFoldDB; A0A452C5C6; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF3; BREAKPOINT CLUSTER REGION PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 90..283
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 300..458
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 485..612
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 646..836
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 40..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 98515 MW; F58C771B72DD1358 CRC64;
MVTACFRQGP LWALHHPTCS TSADAPFGTP PGYSCAMDRA EEQRRHQDGL PYVDDSPSSS
PHLGSKGRGG QDAPEPTKVS ELDLEKGSEM RKWVLSGILA SEETYLSHLE ALLLPMKPLK
AAATTSQPVL TSQQIETIFF KVPELYEIHK EFYDGLLPRL QQWSHQQRVG DLFQKLASQL
GVYRAFVDNY GVAMETAEKC CQANAQFAEI SENLRARSNK DAKDQTTKNS LETLLYKPVD
RVTRSTLVLH DLLKHTPSGH PDHLLLQDAL RISQNFLSSI NEEITPRRQS MTVKKGEHRQ
LLKDSFMVEL VEGARKLRHV FLFTDLLLCT KLKKQSGGKT QQYDCKWYIP LTDLSFQTVD
DSEAAPNIPL VLDEELDAMK IKISQIKSDI QREKRANKGS KAIERLRKKL SEQESLLLLM
SPSMAFRVHS RNGKSYTFLI SSDYERAEWR ENIREQQKKC FKSFSLTSVE LQMLTNSCVK
LQTVHSIPLT INKEDDESPG LYGFLNVIVH SATGFKQSSS LYCTLEVDSF GYFVNKAKTR
VYRDTAEPNW NEEFEIELEG SQTLRILCYE KCYNKSKITK EDGESADRIM GKGQVQLDPQ
ALQDREWQRT IIAMNGIEVK LSVKFTSREF SLKRMPSRKQ TGVFGVKIAV VTKRERSKVP
YIVRQCVEEI ERRGMEEVGI YRVSGVATDI QALKAAFDVN DKDVSVMMSE MDVNAIAGTL
KLYFRELPEP LFTDEFYPNF AEGIALSDPV AKESCMLNLL LSLPEANLLT FLFLLDHLKR
VAEKETVNKM SLHNLATVFG PTLLRPSDKE SKLPANPSQP ISMTDSWSLE VMSQIQIPNK
MLECTLWTIC VPAASRLPLS ASSVSIRSHF
//