ID A0A452C639_BALAS Unreviewed; 497 AA.
AC A0A452C639;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Transcriptional enhancer factor TEF-5 {ECO:0000256|PIRNR:PIRNR002603};
GN Name=TEAD3 {ECO:0000313|RefSeq:XP_028018568.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028018568.1};
RN [1] {ECO:0000313|RefSeq:XP_028018568.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028018568.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor which plays a key role in the Hippo
CC signaling pathway, a pathway involved in organ size control and tumor
CC suppression by restricting proliferation and promoting apoptosis.
CC {ECO:0000256|PIRNR:PIRNR002603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR002603}.
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DR RefSeq; XP_028018568.1; XM_028162767.1.
DR AlphaFoldDB; A0A452C639; -.
DR STRING; 310752.A0A452C639; -.
DR InParanoid; A0A452C639; -.
DR OrthoDB; 1408493at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035329; P:hippo signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 2.70.50.80; -; 1.
DR Gene3D; 6.10.20.40; TEA/ATTS domain; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR027253; TEF-5.
DR InterPro; IPR016361; TEF_metazoa.
DR InterPro; IPR041086; YBD.
DR PANTHER; PTHR11834; TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED; 1.
DR PANTHER; PTHR11834:SF7; TRANSCRIPTIONAL ENHANCER FACTOR TEF-5; 1.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF17725; YBD; 1.
DR PIRSF; PIRSF002603; TEF; 2.
DR PIRSF; PIRSF500720; TEF-5; 2.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS00554; TEA_1; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR002603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002603};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002603};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002603}.
FT DOMAIN 69..145
FT /note="TEA"
FT /evidence="ECO:0000259|PROSITE:PS51088"
FT DNA_BIND 69..145
FT /note="TEA"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00505"
FT REGION 22..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 55704 MW; 276784EAB3691937 CRC64;
MSYLLRKAKL YPSWVWDPPQ ATAQAAQWAQ AQSPEPRATS TIASNSWNAS SSPGEAREDG
PEGLDKGLDN DAEGVWSPDI EQSFQEALAI YPPCGRRKII LSDEGKMYGR NELIARYIKL
RTGKTRTRKQ VSSHIQVLAR KKVREYQVGI KVSSHLQVLA RRKSREIQSK LKAMNLDQVS
KDKALQSMAS MSSAQIVSAS VLQNKFSPPS PLPQAVFSTS SRFWSSPPLL GQQPGPSQDI
KPFAQPAYPV QPPLPPTLSS YEPLAPLPSA AASVPVWQDR TIASSRLRLL EYSAFMEVQR
DPDTYSKHLF VHIGQTNPAF SDPPLEAVDV RQIYDKFPEK KGGLKELYEK GPPNAFFLVK
FWADLNSTIQ EGPGAFYGVS SQYSSADSMT ISVSTKVCSF GKQVVEKVET EYARLENGRF
VYRIHRSPMC EYMINFIHKL KHLPEKYMMN SVLENFTILQ VVTSRDSQET LLVIAFVFEV
STSEHGAQHH VYKLVKD
//
