ID   A0A452C6A7_BALAS        Unreviewed;       773 AA.
AC   A0A452C6A7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN   Name=SLC9A5 {ECO:0000313|RefSeq:XP_028018633.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028018633.1};
RN   [1] {ECO:0000313|RefSeq:XP_028018633.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028018633.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC       membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004195}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR   RefSeq; XP_028018633.1; XM_028162832.1.
DR   AlphaFoldDB; A0A452C6A7; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR018410; Na/H_exchanger_3/5.
DR   InterPro; IPR004709; NaH_exchanger.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF56; SODIUM_HYDROGEN EXCHANGER 5; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   PRINTS; PR01087; NAHEXCHNGR3.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        103..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        136..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        178..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        264..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..389
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          701..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   773 AA;  84888 MW;  5F07BA1B3DCE2374 CRC64;
     MEKVTSLVPE SCLLILLGLV LGGIVLAVAK KAEYQLEPGT FFLFLLPPIV LDSGYFMPSR
     LFFDNLGAIL TYAVVGTLWN AFTTGAALWG LQQAGLVAPR VQAGLLDFLL FGSLISAVDP
     VAVLAVFEEV HVNETLFIIV FGESLLNDAV TVVLYKVCNS FVEMGSANVQ ATDYLKGVAS
     LFVVSLGGAA VGLVFAFLLA LTTRFTKRVR IIEPLLVFLL AYAAYLTAEM ASLSAILAVT
     MCGLGCKKYV EANISHKSRT AVKYTMKTLA SCAETIIFML LGISAVDSSK WAWDSGLVLG
     TLFFILFFRA LGVVLQTWVL NQFRLVPLDK IDQVVMSYGG LRGAVAFALV ILLDRTKIPA
     KDYFVATTIV VVFFTVIVQG LTIKPLVKWL KVKRSEHHKP TLNQELHEHT FDHILAAVED
     VVGHHGYHYW RDRWEQFDKK YLSQLLMRRS AYRIRDQIWD VYYRLNIRDA ISFVDQGGHV
     LSSTGLTLPS MPSRNSVAET SVTNLLRESG SGACLDLQVI DTVRSGRDRE DAVMHHLLCG
     GLYKPRYRKD GMANTEATNG KPPRDLGFQD TAAVILTVES EEEEDSDSSE TEKEDDEGII
     FVARATSEVL QEGKVSGSLE VCPSPRIIPP SPTCAEKELP WKSGQGDLAV YVSSETTKIV
     PVDMQTGWNQ SISSLESLAS PPCTQAPAMT RLPPRSLVTE EPQAPLNLPS DLRPSFAFPP
     SLAKAGRSHS ESSADIPQQQ ELQPLMGHED HTHLSPGTAN SHWCIQFNRG GRL
//