ID   A0A452C8K2_BALAS        Unreviewed;       632 AA.
AC   A0A452C8K2;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE            EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN   Name=P3H3 {ECO:0000313|RefSeq:XP_028019305.1};
OS   Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS   (Balaenoptera davidsoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028019305.1};
RN   [1] {ECO:0000313|RefSeq:XP_028019305.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_028019305.1};
RG   RefSeq;
RL   Submitted (JAN-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate +
CC         trans-3-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:22872, Rhea:RHEA-
CC         COMP:11676, Rhea:RHEA-COMP:11678, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031,
CC         ChEBI:CHEBI:50342, ChEBI:CHEBI:85428; EC=1.14.11.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024148};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC         Evidence={ECO:0000256|ARBA:ARBA00001961};
CC   -!- SIMILARITY: Belongs to the leprecan family.
CC       {ECO:0000256|ARBA:ARBA00006487}.
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DR   RefSeq; XP_028019305.1; XM_028163504.1.
DR   AlphaFoldDB; A0A452C8K2; -.
DR   STRING; 310752.A0A452C8K2; -.
DR   InParanoid; A0A452C8K2; -.
DR   OrthoDB; 5398065at2759; -.
DR   Proteomes; UP000261681; Unplaced.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR   GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   InterPro; IPR039575; P3H.
DR   InterPro; IPR006620; Pro_4_hyd_alph.
DR   InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR   PANTHER; PTHR14049; LEPRECAN 1; 1.
DR   PANTHER; PTHR14049:SF14; PROLYL 3-HYDROXYLASE 3; 1.
DR   Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR   SMART; SM00702; P4Hc; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          460..574
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51471"
FT   REGION          153..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..632
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  71317 MW;  7554FE9A2EE3CDD9 CRC64;
     MFRLLRAWEP LLLRAALRRA ECLTQCGARR LGPGGAARLR VGSALQDAFR RREPYNYLQR
     AYYQLKKLDL AAAAAHTFFV ANPTHLQMRE DMAKYRRMSG VRPQSFRDLE TPPYWQAAYD
     TGLELLGRQE AALALPWLEE ALQESLAQVE SCRAGCEGPE EQQKEEEEEG GTGSQGGLYE
     AIAGHWIGVV QCRQRCVEDT ATRPGRGFPV PDFLPGQLRR LHEAHAQVGN LSQAVENVLS
     VLLFYPEDEA ARKALDQYQA QLGEPRPALG PREDIERFVL RSLGEKRQLY YAMEHLGASF
     KDPDPWTPAA FIPEALREKL REDREKRPWD HEPPQPKPLT HWKDVLLLEG VTLTQDARQL
     NGSERAVLDG LLTPAECGVL LQLAKDAAES GARSGYQGRR SPHTPHERFE GLTVLKAAQL
     ARAGAVGSQG AQLLLEVSER VRSLTQAYFS PDRPLHLSFT HLVCRSAIEG EQAQRMDLSH
     PVHADNCVLD PDTGECWREP PAYTYRDYSG LLYLNDDFQG GDLFFTEPNA LTVTAQVRPR
     CGRLVAFSSG VENPHGVWAV TRGRRCTLAL WHTWAPEHRE QEWTEAKELL QEPEKEEEEE
     MPSRDPAPEP PSHRLQRVQD KAGKPPRVRE EL
//