ID A0A452C8M7_BALAS Unreviewed; 1607 AA.
AC A0A452C8M7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=[histone H3]-trimethyl-L-lysine(4) demethylase {ECO:0000256|ARBA:ARBA00012902};
DE EC=1.14.11.67 {ECO:0000256|ARBA:ARBA00012902};
GN Name=KDM5A {ECO:0000313|RefSeq:XP_028019330.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028019330.1};
RN [1] {ECO:0000313|RefSeq:XP_028019330.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028019330.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-
CC [histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone
CC H3] + 3 succinate; Xref=Rhea:RHEA:60208, Rhea:RHEA-COMP:15537,
CC Rhea:RHEA-COMP:15547, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61961; EC=1.14.11.67;
CC Evidence={ECO:0000256|ARBA:ARBA00000604};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: Belongs to the JARID1 histone demethylase family.
CC {ECO:0000256|ARBA:ARBA00006801}.
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DR RefSeq; XP_028019330.1; XM_028163529.1.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0034647; F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16873; ARID_KDM5A; 1.
DR CDD; cd15602; PHD1_KDM5A; 1.
DR CDD; cd15606; PHD2_KDM5A; 1.
DR CDD; cd15686; PHD3_KDM5A; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR048615; KDM5_C-hel.
DR InterPro; IPR047974; KDM5A_ARID.
DR InterPro; IPR047973; KDM5A_PHD1.
DR InterPro; IPR047970; KDM5A_PHD2.
DR InterPro; IPR047972; KDM5A_PHD3.
DR InterPro; IPR013637; Lys_sp_deMease-like_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR004198; Znf_C5HC2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF17; LYSINE-SPECIFIC DEMETHYLASE 5A; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF21323; KDM5_C-hel; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF08429; PLU-1; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 2..92
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 211..261
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 355..521
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 1079..1136
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1524..1578
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1248..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1607 AA; 182424 MW; 0FCE92E1EA482858 CRC64;
MTRVRLDFLD QLAKFWELQG STLKIPVVER KILDLYALSK IVASKGGFEM VTKEKKWSKV
GSRLGYLPGK GTGSLLKSHY ERILYPYELF QSGVSLMGVQ MPNLDLKEKV EPEVLGTDVQ
TPPEPGTRVN ILPKRTRRVK SQSESGEVNR NTELKKLRIF GAGPKVVGLA MGVKDKEDEV
SRRRKVTNRS DAFNMQMRQR KGTLSVNFVD LYVCMFCGRG NNEDKLLLCD GCDDSYHTFC
LIPPLPDVPK GDWRCPKCVA EECNKPREAF GFEQAVREYT LQSFGEMADN FKSDYFNMPV
HMVPTELVEK EFWRLVSSIE EDVIVEYGAD ISSKDFGSGF PVKDGRRKML PEEEEYALSG
WNLNNMPVLE QSVLAHISVD ISGMKVPWLY VGMCFSSFCW HIEDHWSYSI NYLHWGEPKT
WYGVPSHAAE QLEEVMRELA PELFESQPDL LHQLVTIMNP NVLMEHGVPV YRTNQCAGEF
VVTFPRAYHS GFNQGYNFAE AVNFCTADWL PIGRQCVSHY RRLRRHCVFS HEELIFKMAA
DPECLDVGLA AMVCKELTLL TEEETRLRES VMQMGVLVSQ EEVFELVPDD ERQCAACRTT
CFLSALTCAC NPERLVCLYH PTDLCPCPMQ KKCLRYRYPL EDLPSLLYGV KVRAQSYDTW
VSRVTEALSA NFNHKKDLIE LRVMLEDAED RKYPENDLFR KLRDAVKEAE TCASVAQLLL
SKKQKHRQSP DSGRTRTKLT VEELKAFVQQ LFSLPCVISQ ARQVKNLLDD VEEFHERAQE
AMMDETPDSS KLQMLIDMGS GLYVELPELA RLKQELQQAR WLDEVRLTLS DPQQVTLDVM
KKLIDSGVGL APHHAVEKAM AELQELLTVS ERWEEKAKVC LQARPRHSVA SLESIVNEAK
NIPAFLPNVL SLKEALQKAR EWTTKVEAIQ SGSNYAYLEQ LESLSAKGRP LPVRLDALPQ
VESQVAAARA WRERTGRTFL KKNSSHTLLQ VLSPRTDIGI YGSGKNRRKK VKELIEKEKE
KDLDLEPLSD LEEGLEETRD TATVVAVFKE REQKEIEAMH SLRAANLAKM TMVDRIEEVK
FCICRKTASG FMLQCELCKD WFHNSCVPLP KSSSQKKGSS WQAKEVKFLC PLCMRSRRPR
LETILSLLVS LQKLPVRLPE GEALQCLTER AMSWQDRARQ ALATGELSSA LAKLSVLSQR
MVEQAAREKT EKIISAELQK AAANPDLQGH LPSFQQSAFN RVASSVSSSP RQTVDYDDEE
TDSDADIREA YGYDTKDTAS VKSSSSLEPS LFCDEEIPIK SEEVVTHMWT APSFCAEHAY
SSASKSCSQG SSTPRKQPRX XXXXXXXXXX VLELSPGAKA QLEELMMVGD LLEVSLDETQ
HIWRILQATH PPSEDRFLHI MEDDSMEEKP LKIKGRDSSE KKRKRKLEKV EQLFGEGKQK
SKELKKMDKP KKKKLKLSAE KSKELNKLAK KLAKEEERKK KKEKAAAAKV ELVKESSEKK
REKKVLDIPS KYDWSGAEES DDENAVCAAQ NCQRPCKDKV DWVQCDGGCD EWFHQVCVGV
SPEMAENEDY ICTNCAKKQG PDSPGPAPPP SFIMSYKLPV EDLKETS
//
