ID A0A452CAJ1_BALAS Unreviewed; 1390 AA.
AC A0A452CAJ1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Regulating synaptic membrane exocytosis protein 2 isoform X2 {ECO:0000313|RefSeq:XP_028020092.1};
GN Name=RIMS2 {ECO:0000313|RefSeq:XP_028020092.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028020092.1};
RN [1] {ECO:0000313|RefSeq:XP_028020092.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028020092.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
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DR RefSeq; XP_028020092.1; XM_028164291.1.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF15; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 20..76
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 524..610
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 661..784
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1236..1354
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..829
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..937
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 157061 MW; C9AEE2BC5B0585A4 CRC64;
MYKEQVKKMG EESQQQQEQK GDAPTCGICH KTKFADGCGH NCSYCQTKFC ARCGGRVSLR
SNKVMWVCNL CRKQQEILTK SGAWFYNSGS NTPQQPDQKV LRGLRNEEAP QEKKAKLHEQ
AQFQGPSGDL SVPAVEKSRS HGLTRQDSIK NGSGVKHQIA SDVASDRKRS PSVSRDQNRR
YDQREEREEY SQYATSDSAM PRSPSDYADR RSQREPQFYE ESDHINYRDS NRRSHRHSKE
YIVDDEDAEG RDEYERQRRE EEYQARYRSD PNLARYPVKP QPYEEQMRIH AEVSRARHER
RHSDVSLANS ELEDSRISML RMERPSRQRS VSERRAAMEN QRSYSMERTR EAQGPSSYPQ
RTTNHSPPTP RRSPIPIDRP DMRRTDSLRK QQHLDPSSAV RKTKREKMET MLRNDSLSSD
QSESVRPPPP KPHKSKKGGK MRQVSLSSSE EELASTPEYT SCDDVEIESE SVSEKGDMDY
NWLDHTSWHS SEASPMSLHP VTWQPSKDGD RLIGRILLNK CLKDGSVPRD SGAMLGLKVV
GGKMTESGRL CAFITKVKKG SLADTVGHLR PGDEVLEWNG RLLQGATFEE VYNIILESKP
EPQVELVVSR PIGDIPRIPD STHAQLESSS SSFESQKMDR PSISVTSPMS PGMLRDVPQF
LSGQLSIKLW FDKVGHQLIV TILGAKDLPS REDGRPRNPY VKIYFLPDRS DKNKRRTKTV
KKTLEPKWNQ TFIYSPVHRR EFRERMLEIT LWDQARVREE ESEFLGEILI ELETALLDDE
PHWYKLQTHD VSSLPLPHPS PYMPRRQLHG ESPTRRLQRS KRISDSEVSD YDCDDGIGVV
SDYRHNGRDL QSSTLSVPEQ VMSSNYCSPS GSPHRVDVIG RTRSWSPSVP PPQSRNVEQG
LRGTRSTTGH YNTISRMDRH RVMDDHYSPD RDRSHPRTGS VQTNPSSTPV AGRRGRQLPQ
LPPKGTLERK EVDSTRRRHA GAMDIEERNR QMKINKYKQV AGSDPRLEQD YQSKYRSGWD
PHRGADNIST KSSDSDVSDI SAVSRTSSAS RFSSTSYMSV QSERPRGNKK ISVFTSKMQS
RQMGISGKNM TKSTSISGDM CSLEKNDGSQ SDTAVGALGS SSKKRRSSIG AKMVAIVGLS
RKSRSASQLS QTEAGGKKLR STVQRSTETG LAVEMRNWMT RQASRESTDG SVNSYSSEGN
LIFPGVRLAS DSQFSDFLDG LGPAQLVGRQ TLATPAMGDI QVGMMDKKGQ LEVEIIRARG
LVVKPGSKTL PAPYVKVYLL DNGVCIAKKK TKVARKTLEP LYQQLLSFEE SPQGKILQII
VWGDYGRMDH KSFMGVAQIL LDELELSNMV IGWFKLFPPS SLVDPTLAPL TRRASQSSLE
SSTGPSYSRS
//
