ID A0A452CCW3_BALAS Unreviewed; 688 AA.
AC A0A452CCW3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Transducin-like enhancer protein 2 isoform X3 {ECO:0000313|RefSeq:XP_028020833.1};
GN Name=TLE2 {ECO:0000313|RefSeq:XP_028020833.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028020833.1};
RN [1] {ECO:0000313|RefSeq:XP_028020833.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028020833.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR RefSeq; XP_007176592.1; XM_007176530.1.
DR RefSeq; XP_028020833.1; XM_028165032.1.
DR AlphaFoldDB; A0A452CCW3; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 1..72
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 488..529
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 530..571
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 612..643
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 123..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 73363 MW; 9EA14E906A1F9716 CRC64;
MQRHYVMYYE MSYGLNIEMH KQAEIVKRLS GICAQIIPFL TQEHQQQVLQ AVERAKQVTV
GELNSLIGQQ LQPLSHHAPP VPLTPRPAGL VGGSATGLLA LSGALAAQAQ LAAVAKEDRA
GVEAEGSRVE RAPSRSASPS PPESVAEEER PSGPGGNGKQ RAEEKDLSGP YESDEDKSDY
NLVVDEDQPS EPPTPATTPC GKAPICIPAR RDLVDSPASL ASSLGSPLPR AKELVLNDLP
AGTPASKSCD SSPPQDASTP GPSSTSHLRQ LAAKPAPSTD SIALRSPLTL SSPFTTSFSL
GSHSALNGDL SVPSSYVSLH LSPQVSGSVM YGRSPMMAFE SHPHLRGSSI SSSLPTIPGG
KPAYSFHVSA DGQMQPVPFP SDALVGAGIP RHARQLHTLA HGEVVCAVTI SGSTQHVYTG
GKGCVKVWDV GQPGAKTPVA QLDCLNRDNY IRSCKLLPDG RSLIVGGEAS TLSIWDLAAP
TPRIKAELTS SAPACYALAV SPDAKVCFSC CSDGNIVVWD LQNQTMVRQF QGHTDGASCI
DISDYGTRLW TGGLDNTVRC WDLREGRQLQ QHDFSSQIFS LGHCPNQDWL AVGMESSNVE
ILHVRKPEKY QLHLHESCVL SLKFASCGRW FVSTGKDNLL NAWRTPYGAS IFQSKESSSV
LSCDISGNNK YIVTGSGDKK ATVYEVVY
//
