ID A0A452CE41_BALAS Unreviewed; 1211 AA.
AC A0A452CE41;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 28-JUN-2023, entry version 14.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
DE EC=5.2.1.8 {ECO:0000256|PROSITE-ProRule:PRU00277};
GN Name=FKBP15 {ECO:0000313|RefSeq:XP_028021270.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028021270.1};
RN [1] {ECO:0000313|RefSeq:XP_028021270.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028021270.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000256|PROSITE-
CC ProRule:PRU00277};
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DR RefSeq; XP_028021270.1; XM_028165469.1.
DR AlphaFoldDB; A0A452CE41; -.
DR STRING; 310752.A0A452CE41; -.
DR InParanoid; A0A452CE41; -.
DR OrthoDB; 3152232at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR PANTHER; PTHR44927; FK506-BINDING PROTEIN 15; 1.
DR PANTHER; PTHR44927:SF1; FK506-BINDING PROTEIN 15; 1.
DR Pfam; PF00254; FKBP_C; 1.
DR SUPFAM; SSF54534; FKBP-like; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Rotamase {ECO:0000256|PROSITE-ProRule:PRU00277}.
FT DOMAIN 197..290
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50059"
FT REGION 40..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 567..651
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 49..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 132280 MW; 94EE7F79EE7CABFC CRC64;
MFGAGDEDDT DFLSPSGGTR LASLFGLDQA AAGHGNEFFH YTAPKQPKKG QGTAPTGNQA
TPKTAPATAG TSTVLVATAV HAYRYTNGQY VKQGKFGAAV LGNHTAREYR ILLYISQQQP
VTVARIHLNF ELMVRPNNYS TFYDDQRQNW SIMFESEKAA VEFNKQVCIA KCNSTSSLDS
VLSQDLIVVE GPAVEVGDSL ELAYTSWLFQ NQGLGQVFDS TANKDKLLRL KVGSGKVIKS
WEDGMVGMKK GGKRLLIIPP ACAAGSEGVI GWTPSTDSIL VFEVEIRRVK FARDSGSDGH
SVSSRDSAAP SPIPGADNLS ADPVVSPSTS VPFKSGESVL RSKSNSLSEQ LTVNTNPDTV
KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNALRGAG QPVVTPSIQP SLQPAHPVLP
QMTSQAPQPS VSGLQTPSAA LMQVASHDSH SAVSGNAQSF QPYTGMQAYA YPQAPAVASQ
LQPVRPLYPA PLSQSPHFQG SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL
QKHSTGNSLL IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSSRIEE QNDKISELIE
RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA QVSHLHLKMT
AHQKKETELQ VQLTESMKET DLLRGQLAKL QAEFSELQET SEQAQSKFKS EKQSRRQLEL
RVTSLEEELT DLRAEKESLE KTTGADDGSL VPKNLSERKK KSAQERCQAE EEIDEIRKSH
QEELDKLRQL LKKARVSTDQ AAAEQLSLVQ AELQTQWEAK CEHLLASAKN EHLQQYQEAC
AQRDARQQKL LHLEEKSVLQ CSALQAQVTA LTEQNAQHIK DLESKSQMSG VEAAAAAADP
SEKVKKIMNQ VFQSLRGEFE LEESYNGRTI LGTIMNTIKM VTLRLLNQHE REKGESSNEE
EEEEEEEERP QSASGQSQAP LNRERREPPM VPSEQVVQEA APLPPQALPA PQDDAQRREG
EPSEAEARSE IKEPACLPSR RALGPPTSIP PAPPGLVTVD SEGEEALAAS PLGDACVGEQ
ESSTRLPLTS DPEKVDPLAA GPESPGGEPQ APELQKDEDG TSSAAPSREP HGTEAASAAV
GAVPGSEHRS QHPSLSEDEE DELFKGTALK VPRPKAQAEE EDEDEVSMKG RPPPTPLFGD
DDDDDDIDWL G
//
