ID A0A452CGC5_BALAS Unreviewed; 4047 AA.
AC A0A452CGC5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Extracellular matrix protein FRAS1 {ECO:0000313|RefSeq:XP_028022045.1};
GN Name=FRAS1 {ECO:0000313|RefSeq:XP_028022045.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028022045.1};
RN [1] {ECO:0000313|RefSeq:XP_028022045.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028022045.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_028022045.1; XM_028166244.1.
DR STRING; 310752.A0A452CGC5; -.
DR InParanoid; A0A452CGC5; -.
DR OrthoDB; 5470912at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00064; FU; 11.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 4.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 4.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3941..3961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..123
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 128..188
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 192..252
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 254..314
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 318..378
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 382..452
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1136..1231
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1251..1342
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1363..1472
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1497..1593
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1629..1723
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1744..1844
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1866..1970
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1991..2091
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2112..2211
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2234..2326
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2346..2439
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2474..2571
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 4047 AA; 446852 MW; 5C1F12148B09B009 CRC64;
MAEVNVLIRH VKQQRIPACG GLRQAVHISQ TLSARPVVLV VCSLAPSGGP EIQRLEMCSQ
LSRFRTWCEE KDATVWKPDS CQNCRCHGDI IICKPAVCRN PQCAFEKGEV LQIPANQCCP
ECVLRTPGSC HHEKKIHTHG TEWASSPCSV CSCTHGEVRC TSRPCPPLLC GHQELEFIPE
GSCCPVCVGP GKPCSYEGRV FQDGEDWPLS RCAKCVCRNG VAQCFTAQCH PLFCNQDETV
VRVPGKCCPQ CSSRSCSAAG RVYEHGEQWS ENACTTCICD RGEVRCHRQA CPPLRCEKGQ
RRAQRHGQCC EDCVSPAGSC SHGGLVRYQD EIWKGSACEF CTCDRGQVTC RTGECAKVEC
AQGEELIHLD GKCCPECVSR NGYCVYEENA EFMSSNTSKV KHIPEGEKWQ DGPCKLCECR
GAQVTCYEPS CPPCPVATLA QVVKGQCCPD CTSVHCHPDC LTCSQSPDHC DLCQDPTKML
RNGRCVHSCG LGFYQAGALC LACQRQCSVC TSGLECSSCR PPLLMQHGQC VSACGNGFYQ
DRHSCAACHE SCAACWGPTE KHCLACRDPF QVLREGGCES SCGDGFYNKQ GTCSACDQSC
ESCGPNSPRC LTCAEKTVLH DGKCISECPG GYYADAAGRC KVCHNSCASC SGPSASHCTA
CIYPQALRQG HCLPNCGEGF YPDHGVCKGC HSSCLTCVGP ERSHCTQCKK PEEGLHIEQL
SGANITSGEC LSQCRAQFYL ENTGLCEACH QSCFGCAGKS PHNCTACWPS HVLLDGQCLS
QCPDGYFNLE GSCTECHPTC RQCHGPSESD CISCHPRVTL AGGSCRTSCK EKQFLNLVGY
CADCHPLCQH CAADLYNTGS VCLRCQNARY LLLEDLCVPH CPSGYFAERG ACKKCHCSCR
TCQGRGPFSC SSCDTDLVLS HLGTCSAACF PGHYLDDNHT CQPCNTHCRS CDSQASCTSC
RDPNKVLLLG DCQHESCAPQ YYLDFSTKTC KECDWSCSAC RGPLRTDCLQ CLDGYVLQDG
ACVEQCSPSF YRDLGLCKSC DGHCLQCQGP HECTRCEGPF LLLEAQCVQE CGKGNFADHS
NRKCTACPRG CLRCSHRDRC HLCDHGFLLK SGLCVSNCVP GFPAHSNETC AGKIHTPSLH
VNGSLTLAIG SVKPLDFLLL NVQDQDGRVE DLLFHVVSTP TNGHLVLSRN GKEVQLDKAG
HFSWKDVKEK RVRFVHSKEK PRKGYFSLKI SDQQFFSEPQ LINIQAFSTQ APYVLRNEAL
HISRGERGTI TTQLLDIRDD DNPQDVVVQV LDPPLHGQLL QTLQSPAAPS YQFRLDELSR
GLLQYAHDGS DRTSDVTVLQ ANDGHSFHNI LFRVRTVPKN DRGLRLVANS MVWVPEGGML
QITNRILQAE APGARASEII YKITQDHPQF GEVVLVFNMP ADGPADEGQH LPDGRTATPT
STFTQQDINE GIVWYRHSGV PAQSDSFRFQ VSSAMEAHAR LESRVFNIAI LPQTPEAPKR
SPGASLHMTA REDGLTVIQP HSLSFGNSER PSGKIIYNIT LPLHPSQGII EHRDQPHSPI
RYFTQEDINQ GKIMYRPPTA APHLQEIMAF SFAGLPDSVK FHFTVSDGGH TSPEMALTVH
LLRIDRHPPV FQVTAPLLKV SPGGSTSIGL QLVVRDTETV PEELLFELRK PPQHGVLLKY
TAGFPGPMAS GDTFTYEDVE ENVLQYLHDG SSAREDSMEI SVTDGISAAT VDVRVEVSLS
EAQGPRLAAG ASLSITVASK STAIITRSHL AYVDDSSPDP EIWIQLSSLP AYGALLRTSG
SEVEELSEVS NFTMEDINNK KIRYSAAFET GGHLVTDSFH FSVSDLDHNR LDNQRFTIMI
TPVKDPPQVI AFADLITVDE GGRAPLSFHH FFAADDQDSL QGDAVIKLSA LPKYGCIENT
GTGDRFGPGT TSDLEASFPI QDVLENYIYY FQSVHESIEP THDVFSFYVS DGNSRSEIHR
INITIERKND EPPRMTLRPL GVQLSSGVVI SNSSLSLQDL DTPDNELIFV LTKKPGHGHL
LRRQTASEPL ENGRVLVQGS SFTYQDILAG LVGYMPGGPG VAVDEFQFSL TDGLHTDTGR
MEIYIELPTG DTPHLAVNQG LQLSAGSIAP ITEQHLKVTD TDSDDHQVMY ILKEDPGAGR
LQLVKHDSLE QISVKGPIQS FTQADISQGH IEYSHGKGES GGSFAFKFDV VDGEGNKLIG
RSFSISVLEE DKSPPVITTN KGLVLDENSM KKITTLQLSA TDQETEPAEL IYRITREPQL
GHLEHTASPG IQINSFTQAD LTSGRIQYIH SSETEKRSDA FSFTLSDGVN EVTQTFHITL
RPVDDSLPVV QNLGMRVQEG VRKTITEFEL KAVDADTEAE SVTFMIRQPP RHGTIERTTN
GQPFQHTSSF TMEDVYQNRV RYSHDGSNSL KDWFTFTVAD GTNPFFIIEE GGKEITTAAP
QQFWVDILPV DDGTPRIVTN LGLQWLEYMD GKATNLITKK ELLTVDPDTE DLQLVYEITT
GPEHGHMENK LQPGRAAATF TQEDVNLGLI RYVLHEEKIH EMMDSFQFLV RDSKPNVVSD
NIFHIQWSLI SFKYTSYNVS EKAGSVSITV QRTGNLNQYA IVLCHTEQGT ASSSSRVSSQ
PGQQDYVEYA GQVQFDERED TKSCTVVIND DDVFENVESF TVELSMPAYA LLGEFTQAKV
IINDTEDEPT LEFDKKTYRV NESAGFLFAP IERKGDSSSI VSAICYTVPK SAMGSSLYAL
ESGSDFKSRG MSAESRVIFG RGVTMSTCDV MLIDDSEYEE EEEFEIALAD ASDNARIGSV
ASAKVLITGP NDASTVSLGN TAFTVSEDAG TVKIPLIRHG TDLSTLTSVW CATRPSDPAS
ATPGVDYVPS SRKVDFGPGV TEQYCTLTIL DDTQYPVIEG LETFVVFLSS AQGAELTKPF
QAVIAINDTF QDVPSMQFAK DLLLAKEKEG VLHVPIIRSG DLSYESSVRC YTQGHSAQVM
EDFEERRNTD SSRITFLKGE KMKNCTVYIH DDSMFEPEEQ FRVYLGHPLG NHWSGARVGK
NNMATITISN DEDAPTIEFE EAAYQVREPS GPDATAILNI KVIRRGDQNR TSKIRCSTRD
GSAQSGVDYY PKSRILKFSP GVDHIFFKVE ILSNEDREWH ESFSLVLGPD DPVEAVLGDV
TTATVTILDQ EVSGSLILPA PPIVVTLADY DHVEEVTKEG VKKSPSPGYP LVCVTPCDPH
FPKYAIMKER CSEAGINQTS VQFSWEVATP TDGNGARSPF ETITDNTPFT SVNHMVLDSI
YFSRRFHVRC VAKAVDKVGH VGTPLRSNIV TIGTDSAICH TPVVAGTARG FQAQSFIANL
KYLDVKHKEH PNRIHISVQI PHQDGMLPLI STMPLHNLHF LLSESIYRHQ HVCSNLVTTR
DLRGISEAGF LDDRVHDSTA LGPGYDRPFQ FDASVREPKT ILLYKHLNLK SCVWTFDAYY
DMTELIDICG GSVTADFQVR DSAQSFLTVH VPLYVSYIYV TAPRGWASLE HHTEMEFSFF
YDTVLWRTGI QTDSVLSARL QIIRIYIRED GRLVIEFKTH AKFRGQFVIE HHTLPDVKSF
ILTPDHLGGI EFDLQLLWSA QTFDSPYQLW RATSSYNRKD YSGEYTIYLI PCTVQPTQPW
VDPGEKPFAC TAHAPERFLI PIAFQQTNRP VPVVYSLNTE FQLCNNEKVF LMDPNTSDMS
LAEMDYKGAF SKGQILYGRV LWNPEQNLNS AYKLQLEKVY LCTGKDGYVP FFDPTGTIYN
EGPQYGCIQP NKHLKHSFLL LDRSQPEVTD KYFHDVPFEA HFASELPDFH VVSSMPGVDG
FTLKVDALYK VEAGHQWYLQ VIYIIGPDTI SGPRVQRSLT APLRRNRRDL VDPSGWLTLD
ESLIYDNEGD QVKNGTNMKS LNLEMEEPAV AASLSQTGAS ISSALAAIML LLLVFLVACF
ITRKCQKQRK KPPTGDILEE YPLNTKVDVP KRGPDRVEKN VDRQYCTVRN VNVLGETEGA
YVFKGAKVKK LNLEVRVHNN LQDGTEV
//