ID A0A452CH10_BALAS Unreviewed; 920 AA.
AC A0A452CH10;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|RefSeq:XP_028022319.1};
GN Name=VLDLR {ECO:0000313|RefSeq:XP_028022319.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028022319.1};
RN [1] {ECO:0000313|RefSeq:XP_028022319.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028022319.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_028022319.1; XM_028166518.1.
DR AlphaFoldDB; A0A452CH10; -.
DR STRING; 310752.A0A452CH10; -.
DR InParanoid; A0A452CH10; -.
DR OrthoDB; 3918101at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipoprotein {ECO:0000313|RefSeq:XP_028022319.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_028022319.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 845..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 528..571
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 572..614
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 615..658
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 659..703
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 80..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 87..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 99..114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 119..131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 126..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 181..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 201..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 208..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 220..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 240..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 247..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 286..298
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 293..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 305..320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 325..337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 332..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 344..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 373..391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 447..457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 920 AA; 101054 MW; 35A2B7923D4990EE CRC64;
MDGNRLQAHN PVIPQSFANP KLNSFGVFDS FGALYGSIPS CPSKRTPIHG FQVTGISNLS
SLCPSLAKCS LLILGRKAKC EPSQFQCTNG RCITLLWKCD GDEDCADGSD EKNCVKKTCA
ESDFVCNNGQ CVPNRWQCDG DPDCEDGSDE SPEQCHMRTC RINEISCGAR STQCIPVSWR
CDGENDCDSG EDEENCGNIT CSPDEFTCSS GRCISRNFVC NGQDDCSDGS DELDCTPPTC
GAHEFQCSTS SCIPISWVCD DDADCSDQSD ESLEQCGRQP VIHTKCPASE IQCGSGECIH
KKWRCDGDPD CKDGSDEVNC PSRTCQPDQF ECEDGSCIHG SRQCNGIRDC VDGSDEVNCK
NVNQCLGPGK FKCRSGECID VSKVCNQEQD CRDWSDEPLK ECHVNECLVN NGGCSHICKD
LVIGYECDCA AGFELIDRKT CGDIDECQNP GICSQICINL KGGYKCECSR GYQMDLATGV
CKAVGKEPSL IFTNRRDIRK IGLERKEYIQ LVEQLRNTVA LDADIAAQKL FWADLSQKAI
FSASIDDKVG RHVKMIDNVY NPAAIAVDWV YKTIYWTDAA SKTISVATLD GTKRKFLFNS
DLREPASIAV DPLSGFVYWS DWGEPAKIEK AGMNGFDRRA LVTADIQWPN GITLDLIKGR
LYWLDSKLHM LSSVDLNGQD RRIVLKSLEF LAHPLALTIF EDRVYWIDGE NEAVYGANKF
TGSELATLVN NLNDAQDIII YHALVQPSGK NWCEEDMENG GCEYLCLPAP QINDHSPKYT
CSCPNGYNLE DNGRECQSTA TTVTYSETKD TNTTEMSPTS GLAPGEINVT TAVSEVSVPP
KGTSAAWAIL PLLLLAMAAV GGYLMWRNWQ HKNMKSMNFD NPVYLKTTEE DLSIDIGRHS
ASVGHTYPAI SVVSTDDDLA
//
