ID A0A452CIA5_BALAS Unreviewed; 1706 AA.
AC A0A452CIA5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Unconventional myosin-XVIIIa isoform X2 {ECO:0000313|RefSeq:XP_028022744.1};
GN Name=MYO18A {ECO:0000313|RefSeq:XP_028022744.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028022744.1};
RN [1] {ECO:0000313|RefSeq:XP_028022744.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028022744.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_028022744.1; XM_028166943.1.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:InterPro.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006259; P:DNA metabolic process; IEA:InterPro.
DR CDD; cd01386; MYSc_Myo18; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50163; RECA_3; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 216..268
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 272..1052
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 409..474
FT /note="RecA family profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50163"
FT REGION 1..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1317..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1116..1220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1580..1663
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 50..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 365..372
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1706 AA; 191770 MW; 446E797707E5DBE5 CRC64;
MNGPRTASVE GPSEEAQGLS RKRVANAVRK VVSKVLPVEE PGSAKEPPGR AVRSPEHPAR
GRKGEKAAPG PKLPPPPAPP ARPKSEAEKE AAKDELSVGL RSLMSRGRGK DHRPRGRQPP
GKGEKPSSQE PGSSGKPVSP ETVDSSEKLG SPAQPEELAD PGSADPNLKS NLTGLRQNKS
PAPDVQQELD PEAASPAHSQ VKTEEQIAAE EAWYETEKVW LVHKDGFSLA TQLKSEELSL
PEGKVRVKLD HDGAILDVDE DDVEKANAPS CDRLEDLASL VYLNESSVLH TLRQRYGASL
LHTYAGPSLL VLSPRGAPAV YSEKVMHMFK GCRREDMAPH IYAVAQTAYR AMLMSRQDQS
IILLGSSGSG KTTSCQHLVQ YLATIAGTSG NKVFSVDKWQ ALYTLLEAFG NSPTIMNGNA
TRFSQILSLD FDQAGQVASA SVQTMLLEKL RVARRPAGEA TFNIFYYLLA CGDGTLRTEL
HLNHLAENNV FGIVPLAKPE EKQKAAQQFS KLQTAMKVLG ISPDEQKACW LILAAIYHLG
AAGATKEAAE AGRRQFARHE WAQKAAYLLG CNLEELSSAI FKHQHQGGTL QRSTSFRQGP
EESSLGDGTG PKLSALECLE GMASGLYSEL FTLLISLVNR ALKSSQHSLC SVMIVDTPGF
QNPEQGGSAR GASFEELCHN YAQDRLQRLF HERTFVQELE RYKEENIELA FDDLEPATDD
SVAAVDQASH QSLVRSLART DEAKGLLWLL EEEVLVPGAT EDALLERLFS YYGPQEGDRK
GQGPLLRSSK PHHFLLGHSH GTNWVEYNTA GWLSYTKQNP ATQNAPRLLQ DSQKKIISNL
FLGRAGSATV LSGSIAGLEG GSQLALRRAT SMRKTFTTGM AAVKKKSLCI QIKLQVDALI
DTIKKSKLHF VHCFLPVAEG WAGEPRSAHS RRVSCSSELD LPPGDHCEAG LLQLDAPLLR
AQLRGSRLLD AMRMYRQGYP DHMVFSEFRR RFDVLAPHLT KKHGRNYIVV DEKRAVEELL
ESLDLEQSSC CMGLSRVFFR AGTLARLEEQ RDEQTSRNLT LFQAACRGYL ARQHFKKKKI
QDLAIRCVQK NIKKNKGVKD WPWWKLFTTV RPLIEVQLSE EQIRNKDEEI QQLRSKLEKV
EKERNELRLS SDRLETRISE LTSELTDERN TGESASQLLD AETAERLRAE KEMKELQTQY
DALKKKMEVM EMEVMEARLI RAAEINGEVD DDDTGGEWRL KYERAVREVD FTKKRLQQEF
EDKLEVEQQN RRQLERRLGD LQADSDESQR ALQQLKKKCQ RLTAELQDTK LHLEGQQVRN
HELEKKQRRF DSELSQAHEE AQREKLQREK LQREKDMLLA EAFSLKQQME EKDMDIAGFT
QKVVSLEAEL QDISSQESKD EASLAKVKKQ LRDLEAKVKD QEEELDEQAG TIQMLEQAKL
RLEMEMERMR QTHSKEMESR DEEVEEARQS CQKKLKQMEI QLEEEYEDKQ KVLREKRELE
NKVATLSDQV NQRDFESEKR LRKDLKRTKA LLADAQIMLD HLKNNAPSKR EIAQLKNQLE
ESEFTCAAAV KARKAMEVEI EDLHLQIDDI AKAKTALEEQ LSRLQREKNE IQSRLEEDQE
DMNELMKKHK AAVAQASRDL AQMNDLQAQL EEANKEKQEL QEKVGTRVSL GRERVPGSLC
VGTNSQAHRQ ARASLCHQSA SGSAEA
//
