ID A0A452CPX7_BALAS Unreviewed; 560 AA.
AC A0A452CPX7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Numb-like protein {ECO:0000313|RefSeq:XP_028025046.1};
GN Name=NUMBL {ECO:0000313|RefSeq:XP_028025046.1};
OS Balaenoptera acutorostrata scammoni (North Pacific minke whale)
OS (Balaenoptera davidsoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=310752 {ECO:0000313|Proteomes:UP000261681, ECO:0000313|RefSeq:XP_028025046.1};
RN [1] {ECO:0000313|RefSeq:XP_028025046.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_028025046.1};
RG RefSeq;
RL Submitted (JAN-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
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DR RefSeq; XP_028025046.1; XM_028169245.1.
DR AlphaFoldDB; A0A452CPX7; -.
DR STRING; 310752.A0A452CPX7; -.
DR InParanoid; A0A452CPX7; -.
DR OrthoDB; 2913102at2759; -.
DR Proteomes; UP000261681; Unplaced.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF4; NUMB-LIKE PROTEIN; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261681}.
FT DOMAIN 37..162
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..524
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 59244 MW; DE8E62BEA9519AB7 CRC64;
MNKLRQSLRR RKPAYVPEAS RPHQWQADED AVRKGTCSFP VRYLGHVEVE ESRGMHVCED
AVKKLKAMGR KSVKSVLWVS ADGLRVVDDK TKDLLVDQTI EKVSFCAPDR NLDKAFSYIC
RDGTTRRWIC HCFLALKDSG ERLSHAVGCA FAACLERKQR REKECGPGLG ESLTAPSWKM
GEALGNLPAL FGPEFNLTSI QAAAQPPVSP MSPAEAAAAP TAAPGPAQPG HVSPTPATTS
PGEKGEAGTP VAAGTTAAAI PRRHAPLEQL VRQGSFRGFP ALSQKNSPFK RQLSLRLNEL
PSTLQRRTDF QVKGTVPEME PPSASDSDSI SALCTQISSS FASAGAPAPG PPPASTGTSA
WGEPSVPPAA AFQPGHKRTP SEAERWLEEV SQVAKAQQQQ AASVPAVPPG LQPFPAPVGP
FDAAPAQVAV FLPPPHMQPP FVPAYPGLGY PPMPRVPVVG ITPSQMVANA FCSAAQLQPQ
PATLIGKAGA FPPPAAPSAP GGQARPRPNG APWPPEPAPA PAPELDPFEA QWAALEGKPA
VEKPSNPFSG DVQKTFEIEL
//
