ID A0A452DI60_BOVIN Unreviewed; 340 AA.
AC A0A452DI60;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Rhombotin-2 {ECO:0000256|ARBA:ARBA00040621};
DE AltName: Full=LIM domain only protein 2 {ECO:0000256|ARBA:ARBA00041884};
GN Name=LMO2 {ECO:0000313|Ensembl:ENSBTAP00000009126.5,
GN ECO:0000313|VGNC:VGNC:30934};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000009126.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000009126.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009126.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000009126.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009126.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A452DI60; -.
DR SMR; A0A452DI60; -.
DR Ensembl; ENSBTAT00000009126.5; ENSBTAP00000009126.5; ENSBTAG00000006951.5.
DR VEuPathDB; HostDB:ENSBTAG00000006951; -.
DR VGNC; VGNC:30934; LMO2.
DR GeneTree; ENSGT00940000160199; -.
DR InParanoid; A0A452DI60; -.
DR OMA; MCGGCQQ; -.
DR Reactome; R-BTA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000006951; Expressed in olfactory segment of nasal mucosa and 108 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR CDD; cd09384; LIM1_LMO2; 1.
DR CDD; cd09385; LIM2_LMO2; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR45787; LD11652P; 1.
DR PANTHER; PTHR45787:SF3; RHOMBOTIN-2; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 210..272
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 274..336
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 16..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 37402 MW; 47050EA2090411B1 CRC64;
RVLLALYRRG QFNRRGPIFK DAEGGNSAAS RWRGDSDQLG PSQTPSLGIS CPWYCSGVPS
PCGPCSHSSR RLFGARTQSQ VLSQQSRAVL GASPRSLTAD VGPPTPDARE SHLERVHLWS
AVTVLERGGA SSPPERRSKK RRRSGGGGGG ARAPEGVRAP AAGQPRATKG APPPPGTPPP
SPMSSAIERK SLDPSEEPVD EVLQMPPSLL TCGGCQQNIG DRYFLKAIDQ YWHEDCLSCD
LCGCRLGEVG RRLYYKLGRK LCRRDYLRLF GQDGLCASCD KRIRAYEMTM RVKDKVYHLE
CFKCAACQKH FCVGDRYLLI NSDIVCEQDI YEWTKINGMI
//
