ID A0A452DJF0_BOVIN Unreviewed; 855 AA.
AC A0A452DJF0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transmembrane protein 245 {ECO:0000313|Ensembl:ENSBTAP00000047510.2};
GN Name=TMEM245 {ECO:0000313|Ensembl:ENSBTAP00000047510.2,
GN ECO:0000313|VGNC:VGNC:36055};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000047510.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000047510.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000047510.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000047510.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000047510.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000256|ARBA:ARBA00009773}.
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DR AlphaFoldDB; A0A452DJF0; -.
DR Ensembl; ENSBTAT00000053653.2; ENSBTAP00000047510.2; ENSBTAG00000038794.3.
DR VEuPathDB; HostDB:ENSBTAG00000038794; -.
DR VGNC; VGNC:36055; TMEM245.
DR GeneTree; ENSGT00390000001667; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000038794; Expressed in longissimus muscle and 106 other cell types or tissues.
DR ExpressionAtlas; A0A452DJF0; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR002549; AI-2E-like.
DR PANTHER; PTHR21716; TRANSMEMBRANE PROTEIN; 1.
DR PANTHER; PTHR21716:SF4; TRANSMEMBRANE PROTEIN 245; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 94436 MW; 552D704BC6CD9AD0 CRC64;
MADDGGPEEA LSPRGSPSRV PRVQRPVGAA SGGGGCGETP RTAALALRFD KPIKQAFYNT
GAVLFVCLCC GAAVLVYFIL EAFLRPLLWA VLCGTFLHPF KSSLTRLGRH WLQRLHRAHT
PIVLAALLLP ICFADYGVEA LGEQALRRRR LLLLLGAGGP LLYGLYSLGS YLGVQVLLAH
AGALICCGLD YFNSLWIWTL VVGYVLAVSF KWNASTERYL RAMSIPVWII LLFHLASLAG
AWRIPVFLVI VFLMSVGTLY EKQNGKESSG AELPGQVISM AASTLATLAI SITGYESSTE
DHTSTQPTET MDRGEPPPTL SSSSSPTSPS PPPGRQRSEA GTFLRKKKTS DVYFVSLLWA
IVGVQIWSNL WIVQLLPVPI AVWVLKKLVI HFGVVNFLEK RCSVWWQATE HFLRERQQAL
APWPIIGLGK FLLKVDSKMI IWLEKMLDKI ISIFIIFLLV IGTLLLALLL TAKVHQESVH
MIEVTSNLIN ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH KLHKILGDKV
NNTAVIEKQV LELWDRLYHS WFVKNVSHSG RHRGHKLHIS RQNSWLGDIL DWQDIASFVH
ENIETFLSIL ESLWVVMSRN VSLLFSTITT LLTILFYSGT ALLNFVLSLI IFLTTLFYLL
SSSDEYYKPV KWVISLTPLS QPGPSSNIIG QSVEEAIRGV FDASLKMAGF YGLYTWLTHT
IFGINIVFIP SALAAILGAV PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL VFHLLPTYFV
DTAIYSDISG GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY SAMLVSPTNS
VPTPNQTPWP AQAQR
//
