ID A0A452DK01_CAPHI Unreviewed; 3795 AA.
AC A0A452DK01;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Lysosomal trafficking regulator {ECO:0000313|Ensembl:ENSCHIP00000000142.1};
GN Name=LYST {ECO:0000313|Ensembl:ENSCHIP00000000142.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000000142.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000000142.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000000142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; A0A452DK01; -.
DR STRING; 9925.ENSCHIP00000000142; -.
DR Ensembl; ENSCHIT00000000166.1; ENSCHIP00000000142.1; ENSCHIG00000000114.1.
DR GeneTree; ENSGT00940000156359; -.
DR OMA; MGAPPEF; -.
DR Proteomes; UP000291000; Chromosome 28.
DR Bgee; ENSCHIG00000000114; Expressed in spleen and 17 other cell types or tissues.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3003..3109
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3114..3416
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3606..3640
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 143..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2071..2092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2194..2219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2071..2089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2202..2217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3795 AA; 428375 MW; DA4993675455D346 CRC64;
MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPF SAGIILTKEK NSSSQRSTQE
KLYLEGSAPA GQVSAKVNVF RKSRRQRKTT HRYSVRDARK TQLSTSDSEA NSDDKSIVMT
KYRRSHVLQH FVKQSPKEDH LTAKLNHLST KEQTPPDTMA LENSREMIPR EESNTDILSE
PAALSTISHM NNSPFDLCHV LLSLLEKVCK FDITLNHNSA LAASVVPTLT EFLAGFGDCC
NLSDNLEGQM VSAGWTEEPV ALIQRMLFRT VLHLMSVDIS TAEVMPENLR KNLTELLRAA
LKIRTCLEKQ PDPFAPRQKK TLQEGQEDFV FSKYRHRVLL LPELLEGVLQ ILICCLQSAA
SNPFFFSQAM DLVQEFIQHH GFHLFETAVL QMEWLVVRDG VPPEASGHLK ALISNVMKIM
STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM HHHRDLSGLL VSAFKNQVSK NPFEETADGD
VYYPERCCCI AVCSHQCLRL LQQASLSSTC VQILSGVQNI GICCCMDPKS VIVPLLHAFK
LPALKSCQQH ILNILHKLIL DQLGGAEIPQ KTKKAACNIC TVDSDQLAKL EETLQGNSYN
AEPSSGLSSP SYRFQGILPS SGSEDLLWKW DALEAYQNFV FEEDRLQSVQ IANHICSLIQ
KGNVVVQWKL YNCIFNPVLQ RGVELAHHCQ QLSITSAQTH VCSHHNQCLP QEVLQIYLKT
LPTLLKSRVI RDLFLSCNGV NQIIELNYLD GIRNHSLKAF ETLIISLGEQ QKDSSIPGID
GIDLEQKELS SLNVGTLYNQ QAYSDSQSLS KFYARLKDAY PKKRKSVVQD VHINTINLFL
CVAFLCVSKE AESDRELAND SEDTSGYDST ASEPLQHMLP CFSLESLVLP SPKHMHQAAD
IWSMCRWIYM LSPIFQKQFY RLGGFQVCHK LIFMVIQELF RNPEEEQGRR EGDRNMDENQ
DLNRISQPEI TVKEDLLSLT VKSDPTPAEL SSLKKSADSL GKLESEHLSS INVEQIPAVE
AVPKETKVCM SRERETSLQG IRLLEALLAI CLHGTRACQQ KMELELPNQN LSVETILLEM
RDHLSKSKVM ETELAKPLID ALLRVALGNH SADFEHDDAM TEKSHQSEEE LSSQPGDFSE
EAEDSQCCSF KLLVEEEGYE ADSESNPEDS ESWDDGVDLK PEAESFIASS SPNDLLENLA
QGEIIYPEIC TLELNLLSTG KAKLDVLAHV FESFLKIIRQ KEKNIFLLMQ QGTVKNLLGG
FLSILTQTDS DFQACQRVLV DLLVSLMSSR TCSEELTLLL RIFLEKSPCT EILLLGILKI
VESDITMSPS QYLTFPLLYT PSLSNDVSSQ KCPGILNSKA MGLLRRARVS RCKKEGDSES
FPQQLLSSWH IAPVHLPLLG QPHLSEGFSI SLWFNVECTL EPESATEKGK KTRRRNKSLI
LLDSSFDGTE NNRLEGAAYV NPGERLIGEG CIHMISLGSK ALIIQVWADP HTGTFIFRVC
MDSNDDTKVV LLAQVESQEN IFLPSKWQHL VLTYLQQPQG KKNIHGKISI WISGQRKPDV
TLDFMLPRKT SLSSDSNKTF CMIGHCLSSQ EECLQLAGKW DLGNLLLFNG AKIGSQEAFY
LYACGPNYTS IMPCKYGKPV NDYSKYINKD ILQCEQIREL FMTNKDVDIG LLIESLSVVY
TTYCPAQYTI YEPVIRLKGQ MKTQLSQRPF SSKEVHNILL EPHHLKNLQP TECKTLQGIL
HEIGGTGIFV FLFARVVELS SCEETQALAL RVILSLIKYN QQRIHELENC NGLSMIHQVL
IKQKCIVGFH ILKTLLEGCC GEDIIHINEN GEFKLDVESN AIIQDVKLLE ELLLDWKIWN
KAEHGVWEAL LAALEILIRA DHQQQMFNIK QLLKAQVVHH FLLTCQVLQE HKEGQLISMP
REVCKSFVKI TAEVLGSPPD LELLTIIFNF LLAVHPPTNT YVCHNPTNFY FSLHIDGKIF
QEKVQSIMYL RHSSSGGKSV TSPGFMIISP SDFTASPPEG NSSPSAAPEQ VAASALRSRS
LPALPASSPR IKPRKLTGSL GCSIDKLQSF VEDGVASQPE KWSPLRSSET LEKTKQDAFI
SSCESAKTVC ETEAALSAQA SVSDAPKGAL ELPAVNIDQK DFGAEPRSDD DSPGDESCPR
RPLYLKGLAS FQRSHSTIAS LGLAFPSQNG SAAVGRWPSL VDRNTDDWEN FALSLGYEPR
HSRTTGAHSV TEDCLVPICC GLYELLSGVL LILPDVMLED VMDRLIQADT LLVLVNHPSP
AVQQEVIKLL DAYFNRASKE QKDKFLKNRG FSLLANQLYL HRGTQELLEC FIEMFFGRRI
GLDEEFDLED VKNMGLFQKW SVIPILGLIE TSLYDNVLLH NALLLLLQIL NSCSKVADLL
LDNGLLYVLC NTVATLNGLE KIIPLNEYRL LACDIQQLFI AVTIHACSSS GSQYFRVIED
LIVLLGYLQN SKNRRTQNMA VALQFRVLQA AMEFIRTTAN HDSENLTDSL QSPSAPHHTM
FQKRKSIAGP RKFLLAQTDS LLMKMRSVAS DELHVMMQRR MSQENPVQAT ETELAQRLQR
LTVFAVNRIV YQEFNPDIID ILSTPESTTQ SRTSASQTEI SEENIHHEQP PVFNPFQKEM
FMYLVEGFKV SSVSKTSSSK QQWAKILWSC KETFRMQLGR LLVHMLSPAH PSQERKQIFE
IVREPNHQEI LRDCLSPSLQ HGAKLVLYLS ELIHNHKDEL TEEELDTAEL LMNALKLCGH
KCIPPSASTK SDLIRVIKEE QRKYETEEGV NKANWQKTVN NNQQSLFQRL DSKSKDISKI
AADITQAVSL SQGIERKKVI QHIRGMYKVD LSASRHWQEL IQQLTHDRAV WYDPIYYPTS
WQLDPTEGPN RERRRLQRCY LTIPNKYLLR DRQKSEDVIK PPLSYLFEDK THSSFSSTVK
DKAASESIRV NRRCISVAPS RETAGELLLG KCGMYFVEDN ASDTVESSSL QGELEPASFS
WTYEEIKEVH KRWWQLRDNA VEIFLTNGRT LLLAFDNTKV RDDVYHNILT NNLPNLLEYG
NITALTNLWY TGQITNFEYL THLNKHAGRS FNDLMQYPVF PFILADYVSE TLDLSDPSVY
RNLSKPIAVQ YKEKEDRYVD TYKYLEEEYR KGAREDDPMP PVQPYHYGSH YSNSGTVLHF
LVRMPPFTKM FLAYQDQSFD IPDRTFHSTN TTWRLSSFES MTDVKELIPE FFYLPEFLVN
REGFDFGVRQ NGERVNHVNL PPWARNDPRL FILIHRQALE SDCVSQNICQ WIDLVFGYKQ
KGKASVQAIN VFHPATYFGM DVSAVEDPVQ RRALETMIKT YGQTPRQLFQ SAHASRPGSK
LNIEGELPAA VGLLVQFAFR ETREQVKEIT YPSPLSWIKG LKWGEYVGSP SAPVPVVCFS
QPHGERFGCL QALPTRAICG LSRNFCLLMT YSKEQGVRSM NSTDIQWSAI LSWGYADNIL
RLKSKQSEPP INFIQSSQQY QVTSCAWVPD SCQLFTGSKC GVITAYSNRF TSCTPSEIEM
ESQIHLYGHT EEITSLFVCK PYSVMISVSR DGTCIIWDLN RLCYVQSLAG HKSPVTAVSA
SETTGDIATV CDSAGGGSDL RLWTVNGDLV GHVHCREIIC SVAFSNQPEG ISINVIAGGL
ENGIVRLWST WDLKPVREIT FPKSNKPIVS LTFSCDGHHL YTANSDGTVI AWCRKDQQRL
KHPMFYSFLS SYAAG
//
