ID   A0A452DKX6_CAPHI        Unreviewed;       506 AA.
AC   A0A452DKX6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=DiGeorge syndrome critical region gene 2 {ECO:0000313|Ensembl:ENSCHIP00000000490.1};
GN   Name=DGCR2 {ECO:0000313|Ensembl:ENSCHIP00000000490.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000000490.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000000490.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452DKX6; -.
DR   Ensembl; ENSCHIT00000000515.1; ENSCHIP00000000490.1; ENSCHIG00000000347.1.
DR   GeneTree; ENSGT00390000017655; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   Bgee; ENSCHIG00000000347; Expressed in cerebellum and 16 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR042378; IDD.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR15256; INTEGRAL MEMBRANE PROTEIN DGCR2/IDD; 1.
DR   PANTHER; PTHR15256:SF6; INTEGRAL MEMBRANE PROTEIN DGCR2_IDD; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SMART; SM00214; VWC; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR   PROSITE; PS01208; VWFC_1; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..506
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019578302"
FT   TRANSMEM        309..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          83..225
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000259|PROSITE:PS50041"
FT   REGION          28..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..413
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  55385 MW;  000013C113837A07 CRC64;
     MVPKADRGAF LLLFLLVLTV TEPLRPEVSG QARPYHGKEA VDPRPGRARG GDPSHPHAMS
     VAQPVRFSSF LGKCPAGWHH YEGTASCYRA YLSGQSYWDA AQTCQRLNGS LATFSTDQEL
     RFVLAQEWEQ PERSFTWQDQ HKLWVGYQYV VTGRNRSLEG HWEVASKGSS EVLLPPDAIL
     AAATAEGDGV FCAQLQCFHF PTLRHHDLHS WRAESCQDKS SFLCKRSQTC VDIKDNVVDE
     GFYFTPKGDD PCLSCTCHGG EPEMCVAALC ERPQGCQQYR KDPTECCKFV CLDPDGGSLL
     DSMASGMRLV VSCVSSFLVL SLLLFMVHRL RQRRRERIES LIGANLHHFN LGRRIPGFDY
     GPDGFGTGLT PLHLSDDGEG GTFHFHDPPP PYTAYKYPDI DQPDDPPPPY EASINPDSVF
     YDPADDDAFE PAEAAPPTAG DRSGEGTVPR RPERTPGAPL ADLEDSADSS SALLAPPEPG
     PGGGAPTPEA LPGCSRHSRG SLNTVV
//