ID A0A452DL34_CAPHI Unreviewed; 1920 AA.
AC A0A452DL34;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Discs large MAGUK scaffold protein 5 {ECO:0000313|Ensembl:ENSCHIP00000000550.1};
GN Name=DLG5 {ECO:0000313|Ensembl:ENSCHIP00000000550.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000000550.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000000550.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000000550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017897746.1; XM_018042257.1.
DR Ensembl; ENSCHIT00000000576.1; ENSCHIP00000000550.1; ENSCHIG00000000389.1.
DR GeneID; 102170667; -.
DR CTD; 9231; -.
DR GeneTree; ENSGT00940000155303; -.
DR OrthoDB; 2877432at2759; -.
DR Proteomes; UP000291000; Chromosome 28.
DR Bgee; ENSCHIG00000000389; Expressed in ovary and 17 other cell types or tissues.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR006907; DLG5_N.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF16610; dbPDZ_assoc; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF04822; Takusan; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..90
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 620..710
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 705..796
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1349..1428
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1502..1583
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1594..1662
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1776..1906
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 116..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1432..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 146..264
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 303..358
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 383..599
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 879..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1060
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1920 AA; 213654 MW; B160EACB63E7A4DD CRC64;
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG AKAELLLKLL
LAKERDHFHD LRAALEKTQP HLLPILYLNG VVGPPQPAEG AGSTYSVLSI MPSDSESSSS
LSSVGTTGKA PSPPPVLSDR QVNEKVENLS IQLRLMTRER NELRKRLAFA THGTTFDKRP
YHRLNPDYER LKIQCVRAMS DLQSLQSQHT NALRRCEEVA KETDFYHTLH SRLLSDQTQL
KDDVDMLRRE NGQLLRERNL LQQSWEDMKR LHEEDQKEIG DLRAQQQQVL KHNGSSEILN
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAI HSSDLSRLEQ LEEENQRLLK QTEMLTQQRD
TAIQLQHQCA LSLRRFEAIH HELNKATAQN KDLQWEMELL QSELTELRTT QAKTAKESEK
YKEERDAVYS EYKLIMSERD QVISELDKLQ TEVELAESKL KSSTSEKKAA SEEMEALRQI
KDTVTMDAGR ANKEAEILRK QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI
RTLCDNLRRE RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMESQL EKEARFRQLM
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCLPG DCGIFVTKVD
KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG AINMVVRRRK SLGGKVVTPL
HINLSGHKDS GISLENGVYA AAVVPGSPAA KEGSLAVGDR IVAINGIALD NKSLNECESL
LRSCQDSLTL SLLKVFPQSA SWSGQNIFEN IKDSDKMLSY RAHGPEVQAQ NKRNLMQHNN
STQTDIFYAD RLEDRKELGP PGGSSSFLHK PFSGGPFSVS PQACPSASER SLSSFRSDAS
GERGYGPADV RSRRPLLPFE TEVGPCGAAE APLDKAEPDN THSGGTWPKA VLSSMAGPEK
LSVYRKPKQR KSIFDPNTFK RPQTPPKIDY LLPGSGPAHS PLPSKRVGPL TPPKPPRRGD
SIKFQHKLET SSESEATLVG SSPSTSPPSA LPPDMDPGDP MHASPPRKAR VRIASSYCPE
GDRDPSCLPA KKSCDEDLTS QKADELGQKR RRPKSAPIFR PKLAPVVIPA QFLEEQKCTP
ASGELSPDLQ EWSPYSPGHS SRHSNPPFYP SRASVGTVPR SMAPSTVSSV LRNPIYTVRS
HRVGPCSSPP IPREVGPHGL HPSVQHQGRL SLDLSPRACS DCSDMRASHG SNSLPSSARL
GSSSNLQFKA ERIKIPSTPR YPRSVVGSDR GSLSHSECST PPQSPLSVEG LSSCSQPQTS
AATLPRIAVN PAAPGERRKD RPYVEEPRHV KLQKGSEPLG ISIVSGEKGG VYVSKVTGGS
IAHQAGLEYG DQLLEFNGIN LRSATEQQAR LIIGQQCDTI TILAQYNPHM HQLSSHSRSS
SHLDPAGIHS TLQGSGATTP EHPSVIDPLM EQDEGPGTPP AKQSTPSSRT VGDATKKTPE
PRVVFIKKSQ LELGVHLCGG NLHGVFVAEV EDDSPAKGAD GLVPGDLILE YGGLDVRSKT
VEEVYVEMLK PKDSVRLKVQ YRPEEFSKVK GLPGDSFYIR ALYERLAEVE PELSFKKDDI
LYVDDTLPQG SFGSWMAWQL DENAQKIQRG QIPSKYVMDQ EFSRRLSMSE VKDENSAAKT
LSAAARRSFF RRKHKHKRSG SKDGKDLLAL DTFSNDSIPL FEDSVSLAYQ RVQKVDCTSL
RPVLILGPFL DVVKEMLVNE APGKFCRCPL EVMKASQQAI ERGVKDCLFV DYKRRSGHFD
VTTVASIKEI TEKNRHCLLD VAPHAIERLH HMHIYPIVIF IHYKSAKHIK EQRDPIYLKD
KVTQRHSKEQ FETAQKIEQE YSRYFTGVVQ GGALSSICTQ ILAVVNQEQN KVLWIPACPL
//
