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Database: UniProt
Entry: A0A452DMM5_CAPHI
LinkDB: A0A452DMM5_CAPHI
Original site: A0A452DMM5_CAPHI 
ID   A0A452DMM5_CAPHI        Unreviewed;       911 AA.
AC   A0A452DMM5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO6 {ECO:0000313|Ensembl:ENSCHIP00000001000.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000001000.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000001000.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000001000.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017903388.1; XM_018047899.1.
DR   AlphaFoldDB; A0A452DMM5; -.
DR   Ensembl; ENSCHIT00000002231.1; ENSCHIP00000001000.1; ENSCHIG00000000850.1.
DR   GeneID; 102169459; -.
DR   CTD; 196527; -.
DR   GeneTree; ENSGT00940000158969; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000291000; Chromosome 5.
DR   Bgee; ENSCHIG00000000850; Expressed in testis and 17 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        299..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        460..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        507..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        555..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        671..694
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        722..746
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        825..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          62..285
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
SQ   SEQUENCE   911 AA;  106207 MW;  E45712F120C03B2C CRC64;
     MPMMTRDVLL EMELEEDDEE DGDIALENLE QTIVSGFGSL ESQQDFRTPE FEEFNGKPDS
     LYFNDGQRRI DFVLVYEDES RKETNKKGSN EKQRRKRQAY ESNLICDGLQ LEATRSLVDD
     KLVFVKVHAP WEVLCTYAEI MHIKLPLKPN DLKTRSSAFD NFNWFTKLLQ VDESIIKPEQ
     EFFTAPFEKN RMNDFYIQDR DTFFNPATRS RIVYFILSRI MYQVRDNVKK FGINKLVSSG
     IYKAAFPLHD CNFSSPSEDL SCPNERYLLY REWAHPRSIY KKQPLDLIRK YYGEKIGIYF
     AWLGYYTQML LLAAIVGVAC FLYGYFTQNN CTWSKEVCDP DIGGQIIMCP QCDKECPFWS
     LNVTCESSKK LCIFDSFGTL VFAVFMGVWV TLFLEFWKRR QAELEYEWDT VELQQEEQAR
     PEYEARCTHV VINEITQEEE RVPFTTWGKC IRVTLCASAV FFWILLIIAS VIGIIVYRLS
     VFVIFSVNLR KISNGTDPIQ KYVTPQMATS ITASLISFII IMILNTIYEK VAIMITNFEL
     PRTQTDYENS LTMKMFLFQF VNYYSSCFYI AFFKGKFVGY PGDPVYWLGK YRNEECDPGG
     CLFELTTQLI IIMGGKAIWN NIQEVLLPWV MNVFGRCHTV SGAEKIIPRW EQDYHLQPMG
     KLGLFYEYLE MIIQFGFVTL FVASFPLAPL LALVNNILEI RVDAWKLTTQ YRRMVPEKAQ
     DIGAWQPIMQ GIAILAVVTN AMIIAFTSDM IPRLVYYWSF SIPPYGDHPD YTMEGYINIS
     LSIFNTADFK SRVKESPYAG SKYDTCRYRD FRYPPGHQQE YKHNIYYWHV IAAKLAFIIV
     MEHIIYSVKF FISYAIPDVS KSTKSKIKRE KYLTQKLLHE NHLKDMTKNI GVIAEKMIGA
     AVENSLRPKS D
//
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