ID A0A452DMM5_CAPHI Unreviewed; 911 AA.
AC A0A452DMM5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO6 {ECO:0000313|Ensembl:ENSCHIP00000001000.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000001000.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000001000.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000001000.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017903388.1; XM_018047899.1.
DR AlphaFoldDB; A0A452DMM5; -.
DR Ensembl; ENSCHIT00000002231.1; ENSCHIP00000001000.1; ENSCHIG00000000850.1.
DR GeneID; 102169459; -.
DR CTD; 196527; -.
DR GeneTree; ENSGT00940000158969; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000291000; Chromosome 5.
DR Bgee; ENSCHIG00000000850; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 299..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 460..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 507..528
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 555..573
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 671..694
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 722..746
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 825..846
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 62..285
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
SQ SEQUENCE 911 AA; 106207 MW; E45712F120C03B2C CRC64;
MPMMTRDVLL EMELEEDDEE DGDIALENLE QTIVSGFGSL ESQQDFRTPE FEEFNGKPDS
LYFNDGQRRI DFVLVYEDES RKETNKKGSN EKQRRKRQAY ESNLICDGLQ LEATRSLVDD
KLVFVKVHAP WEVLCTYAEI MHIKLPLKPN DLKTRSSAFD NFNWFTKLLQ VDESIIKPEQ
EFFTAPFEKN RMNDFYIQDR DTFFNPATRS RIVYFILSRI MYQVRDNVKK FGINKLVSSG
IYKAAFPLHD CNFSSPSEDL SCPNERYLLY REWAHPRSIY KKQPLDLIRK YYGEKIGIYF
AWLGYYTQML LLAAIVGVAC FLYGYFTQNN CTWSKEVCDP DIGGQIIMCP QCDKECPFWS
LNVTCESSKK LCIFDSFGTL VFAVFMGVWV TLFLEFWKRR QAELEYEWDT VELQQEEQAR
PEYEARCTHV VINEITQEEE RVPFTTWGKC IRVTLCASAV FFWILLIIAS VIGIIVYRLS
VFVIFSVNLR KISNGTDPIQ KYVTPQMATS ITASLISFII IMILNTIYEK VAIMITNFEL
PRTQTDYENS LTMKMFLFQF VNYYSSCFYI AFFKGKFVGY PGDPVYWLGK YRNEECDPGG
CLFELTTQLI IIMGGKAIWN NIQEVLLPWV MNVFGRCHTV SGAEKIIPRW EQDYHLQPMG
KLGLFYEYLE MIIQFGFVTL FVASFPLAPL LALVNNILEI RVDAWKLTTQ YRRMVPEKAQ
DIGAWQPIMQ GIAILAVVTN AMIIAFTSDM IPRLVYYWSF SIPPYGDHPD YTMEGYINIS
LSIFNTADFK SRVKESPYAG SKYDTCRYRD FRYPPGHQQE YKHNIYYWHV IAAKLAFIIV
MEHIIYSVKF FISYAIPDVS KSTKSKIKRE KYLTQKLLHE NHLKDMTKNI GVIAEKMIGA
AVENSLRPKS D
//