ID   A0A452DRZ6_CAPHI        Unreviewed;       626 AA.
AC   A0A452DRZ6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Coiled-coil domain-containing protein 22 {ECO:0000256|ARBA:ARBA00016694};
GN   Name=CCDC22 {ECO:0000313|Ensembl:ENSCHIP00000002475.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000002475.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000002475.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CCDC22 family.
CC       {ECO:0000256|ARBA:ARBA00006438}.
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DR   RefSeq; XP_017900628.1; XM_018045139.1.
DR   AlphaFoldDB; A0A452DRZ6; -.
DR   STRING; 9925.ENSCHIP00000002475; -.
DR   Ensembl; ENSCHIT00000007784.1; ENSCHIP00000002475.1; ENSCHIG00000005594.1.
DR   GeneID; 102188483; -.
DR   KEGG; chx:102188483; -.
DR   CTD; 28952; -.
DR   GeneTree; ENSGT00390000003809; -.
DR   OMA; KFEQHIQ; -.
DR   OrthoDB; 9179at2759; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   Bgee; ENSCHIG00000005594; Expressed in ovary and 18 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0097602; F:cullin family protein binding; IEA:Ensembl.
DR   GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:Ensembl.
DR   GO; GO:0006878; P:intracellular copper ion homeostasis; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   InterPro; IPR008530; CCDC22.
DR   InterPro; IPR048348; CCDC22_CC.
DR   InterPro; IPR048349; CCDC22_N.
DR   PANTHER; PTHR15668:SF4; COILED-COIL DOMAIN-CONTAINING PROTEIN 22; 1.
DR   PANTHER; PTHR15668; JM1 PROTEIN; 1.
DR   Pfam; PF05667; CCDC22_CC; 1.
DR   Pfam; PF21674; CCDC22_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT   DOMAIN          1..109
FT                   /note="CCDC22 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21674"
FT   DOMAIN          127..596
FT                   /note="CCDC22 coiled-coil"
FT                   /evidence="ECO:0000259|Pfam:PF05667"
FT   COILED          326..367
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          449..523
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   626 AA;  70568 MW;  05282D10C2BCD721 CRC64;
     MEEADRILIH SLRQAGTAVP PDVQTLRAFT TELVVEAVVR CLRVINPAVG SGLSPLLPLA
     MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL LLFLAERLPT DASEDADQSA
     GESAILRAIG SRIRDHLALP WVPPLLRTPK LQYLQGSAHQ KPFHASRLVM PELSSKGESR
     EFQAGPLLLP VPTQVPQLAT RAASLLEHHA IQLCQHTGRD RAGDEAWGHR TSRLPAQEDT
     RAQRQRLQKH LAEHLRQTWG RPGPPQQARD LGELLQAWGA GTRPGAPKGS RFTHSKKFTF
     HLEPEAQAAQ VSDVPATSQR PEQDTWAAQE QELESLREQL EGVNHNIEEV EANMKTLGIN
     LVQVETECRQ SELSIVEREQ ALRLKSQAVE LLPDGAANLA KLQLVVESSA QRVIHLAGQW
     EKHRVPLLAE YRHLRKLQDC RELESSRRLA EIQELHQSVR AAAEEARRKE EVYKQLVSEL
     ETLPKDVSRL AYTQRILEIV GNIRKQKEEI TKILSDTKEL QKEINSLSGK LDRTFAVTDE
     LVFKDAKKDD AVRKAYKYLA ALHENCSQLI QTIEDTGTIM REVRDLEEQI ETEMGKKTLS
     NLDKIREDYR ALRQENAGLL GRVREA
//