ID A0A452DVU4_CAPHI Unreviewed; 453 AA.
AC A0A452DVU4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Growth/differentiation factor 9 {ECO:0000256|ARBA:ARBA00017637};
GN Name=GDF9 {ECO:0000313|Ensembl:ENSCHIP00000003958.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000003958.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000003958.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000003958.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer or heterodimer (Potential). But, in contrast to
CC other members of this family, cannot be disulfide-linked.
CC {ECO:0000256|ARBA:ARBA00026064}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452DVU4; -.
DR Ensembl; ENSCHIT00000011262.1; ENSCHIP00000003958.1; ENSCHIG00000008167.1.
DR GeneTree; ENSGT00940000159784; -.
DR OMA; TWRICVC; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000008167; Expressed in ovary and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0001555; P:oocyte growth; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000870; P:regulation of progesterone secretion; IEA:Ensembl.
DR CDD; cd19403; TGF_beta_GDF9; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR015617; Growth_differentiation_fac-9_C.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF19; GROWTH_DIFFERENTIATION FACTOR 9; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..453
FT /note="Growth/differentiation factor 9"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019467077"
FT DOMAIN 315..453
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 282..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 51917 MW; B57C273EFFD81C48 CRC64;
MALPNKFFLW FCCFAWLCFP ISLDSLPSRG EAQIVARTAL ESEAETWSLL NHLGGRHRPG
LLSPLLKVLY DGHGEPPRLQ PDDRALRYMK RLYKAYATKE GTPKSNRRHL YNTVRLFTPC
AQHKQAPGDL AAGTFPSVDL LFNLDRVTVV EHLFKSVLLY TFNNSISFPF PVKCICNLVI
KEPEFSSKTL PRAPYSFTYN SQFEFRKKYK WMEIDVTAPL EPLVASHKRN IHMSVNFTCA
KDQLQHPSAR DSLFNMTLLV APSLLLYLND TSAQAFHRWH SLHPKRKPSQ GPDQRRELSA
YPVGEEAAEG VRSSRHRRDQ ESVSSELKKP LVPASVNLSE YFKQFLFPQN ECELHDFRLS
FSQLKWDNWI VAPHKYNPRY CKGDCPRAVG HRYGSPIHTM VQNIIHEKLD SSVPRPSCVP
AKYSPLSVLA IEPDGSIAYK EYEDMIATKC TCR
//
