ID A0A452DWG7_CAPHI Unreviewed; 905 AA.
AC A0A452DWG7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=SRCR domain-containing protein {ECO:0000259|PROSITE:PS50287};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000004121.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000004121.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000004121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452DWG7; -.
DR Ensembl; ENSCHIT00000011494.1; ENSCHIP00000004121.1; ENSCHIG00000008296.1.
DR GeneTree; ENSGT00940000157963; -.
DR OMA; ANCSESH; -.
DR Proteomes; UP000291000; Chromosome 5.
DR Bgee; ENSCHIG00000008296; Expressed in thymus and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 6.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071:SF24; SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M130-RELATED; 1.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 6.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 6.
DR SUPFAM; SSF56487; SRCR-like; 6.
DR PROSITE; PS00420; SRCR_1; 3.
DR PROSITE; PS50287; SRCR_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 747..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..125
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 128..228
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 233..331
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 367..467
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 505..605
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 624..724
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 826..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 50..114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 63..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 94..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 166..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 197..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 300..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 392..456
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 405..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 436..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 530..594
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 543..604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 574..584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 649..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 662..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 693..703
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 905 AA; 97299 MW; 3F9E8522E39647E6 CRC64;
VFLEKHLSAF KLCAARPSHT HWPAIRLADG GGRCSGRVEI LDQGSWGTIC DDHWDLDDAR
VVCRQLGCGE ALSAMGSAHF GAGSGPIWLD EVSCRGEESQ VWRCPAWGWQ QHNCNHQEDA
GVICSGFVRL VGGDGPCSGR VEVRSGEAWT PVSDGNFTLP TAQVICAELG CGKAVSVLGQ
VPFRESDGWV WAEEFRCEGE EPKLWSCPRV PCPGGTCHHS GAAQVVCSVY TDVRLMTNGT
SQCEGQVEMN ISGRWRALCA SHWSLANANV VCRQLGCGVA ISTPNGAEGS DQLWKARFHC
SGTESFLWTC PVTALGVPDC SHGNTASVIC SGNRSQVLPQ CNDSVSEQAG SAASEESAPY
CSDSRQLRLV DGGGPCAGRV EILDQGSWGT ICDDGWDLDD ARVVCRQLGC GEVLNATGSA
HFGAGSGPIW LDDLNCTGKE SHVWRCPSRG WGRHDCRHKE DAGVICSGPR CTLSTDQQCS
TSLTHCVGCS LCPVSSLSIS EFLALRMVSE DQECAGWLEV FYNGTWGSVC RSPMEDITVS
MICRQLGCGD SGSLNTSVGL REGSRPRWVD GIQCQKTDTS LWQCPSDPWK YSSCSPKEEA
YISCAGRRPK SCPTAAPCTD REKLRLRGGD SKCSGRVEVW HSGSWGTVCD DSWSLAEAEV
VCQQLGCGQA LEAVRAATFG PGNGSIWLDE VRCGGRESSL WDCAAEPWGQ SDCKHEEDAG
VRCSGVRKTL PPTPAGSRPV SSPLPGIFSL PGVLCLILGS LLFLVLVILV TQVFRWRAER
RALFSYEDAL AEAMYEELDH LVTQKESLLG SPDQKTYALG EGYDDAEEVP VPGALPTSEG
SEEEMPPEKE DGMKSEIGSS LNVFREEADP GEGEESPWLL QGEKGYLGYD DVELSALGTS
TVTFP
//
