ID A0A452DXP5_CAPHI Unreviewed; 1383 AA.
AC A0A452DXP5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Adhesion G protein-coupled receptor F5 {ECO:0000313|Ensembl:ENSCHIP00000004554.1};
GN Name=ADGRF5 {ECO:0000313|Ensembl:ENSCHIP00000004554.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000004554.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000004554.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000004554.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; LWLT01000028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005696435.2; XM_005696378.3.
DR STRING; 9925.ENSCHIP00000004554; -.
DR Ensembl; ENSCHIT00000012018.1; ENSCHIP00000004554.1; ENSCHIG00000008724.1.
DR GeneID; 102185129; -.
DR CTD; 221395; -.
DR GeneTree; ENSGT00940000154603; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000291000; Chromosome 23.
DR Bgee; ENSCHIG00000008724; Expressed in metanephros cortex and 17 other cell types or tissues.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl.
DR GO; GO:0048821; P:erythrocyte development; IEA:Ensembl.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IEA:Ensembl.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:Ensembl.
DR GO; GO:0071073; P:positive regulation of phospholipid biosynthetic process; IEA:Ensembl.
DR GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1383
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019584873"
FT TRANSMEM 1051..1070
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1091..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1257..1277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1283..1306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..274
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 275..367
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 508..602
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1049..1307
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1363..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1383 AA; 153872 MW; 7DA5B2FDD263ABED CRC64;
MKSPRRTTLC FVIIAIYSSQ ATLSLNLESI VYHSLLREHE LMEEDPVRPK RAVAVSSPAA
QEFTIDVEIS FENASFLEPI KAYLNNLSFP IQGNDTDLAT DILSIEVSTV CRPNGNEIWC
SCETGYEWPQ ESCLHNLTCQ GHDGSSAGRH CHCLKGLPPK GPFCQLQGDV ILRMSVRLNV
GFQEDLRNSS SALYKSYTTD LETAFWKGYS ILPGFKLVTV TGFRPGSVVV TYEITTTTTT
SPALMHKANE KVTQNLNQTY KVDSSSFQVT YSNETKFSIT PEIIFEGDTV TLMCENEVFS
TNVSWMHVET GLDIQNSTEV SIYTSMLNNM TSMSRLIIHN ITRVYMGEYI CKLTLDIFEY
ASRRKLEVIP IQILASEAVE VMCDNNPVSL NCCSEVNVNW SQIEWKQEGS ISIPGNAEID
TDSGCSRYTL MANETQCPSG SSGTTVVYTC EFISAHGARG RKDIEVTFIS VGDNSSHKGE
VRESQRLVME MSTVQSTTKN SLETSKAPEQ QAKLNITPDL ISVSEGQSFF IKCISDMSNY
DEMYWNTSAG TKIYKRFYTT RRYSDRAESV LTVKTSTREW NGTYHCVFRY KNLYRVMAKD
VIVYPLPLES NIMVDPVEAA IPCRSSRHIR CCVEEDSDYK VIFQVGSSSF PAVKEVDEKQ
VCYKHHFTAD SVSCPENVDA FCHFTNAANN SVQSPSMKLN LVPGESITCQ DPILGVGEPG
KVIQKLCQFL NITRSRESPI GGIITYRCVG SQWQIEKNDC ISAPINALLQ LAKALVKSPT
QDEKLPSYLG NLSISTKQAK LEVDSFSGTL GAIINILDLF STVPTQVNSE MMTHVLSTVD
IILGKSALNT WKISQQQKTN YSSQLLDSVE RFSRVLRAED STISQPNVQM KSMVIKPGHP
QSYRQSFVFL DSDLWGNVTI SGCQLEHLQP DSFVVTVAFP TLKTILDRDV LGENFANSLV
MTTTVSHSVT TPFRILMTFK NSHPSGGIPQ CVFWNFNLAN HTGGWDSSGC YVKEVTEDSV
SCSCEHLTSF SILMSPDSPD PDSLLKILLD IISYIGLCFS ILSLAACLVV EAMVWKSVTK
NRTSSMRHTC IVNITASLLV ADVWFIVAAA IHDHRFPLNE TACVAATFFI HFFYLSVFFW
MLTLGLMLFY RLVFILHDTS KSIQKTIAFS LGYGCPLVIS VITVGATQPR EVYMRKNACW
LNWEDTKALL AFVIPALIIV VVNMTITVVV ITKILRPSIG DKPSKQEKSS LFQVTKSIGV
LTPLLGLTWG FGLATVFQGS NAVFHIVFTL LNAFQGLFIL LFGCLWDQKV QEALLNKYSR
SKWSSQHSKS TSIGSSTPVF SMSSPISRRF NNLFGKTGTY NVSTPETTSS SLENTSSAYS
LLN
//
