ID A0A452DYB5_CAPHI Unreviewed; 528 AA.
AC A0A452DYB5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Lysophosphatidylcholine acyltransferase 1 {ECO:0000313|Ensembl:ENSCHIP00000004672.1};
GN Name=LPCAT1 {ECO:0000313|Ensembl:ENSCHIP00000004672.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000004672.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000004672.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000004672.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; phospholipid metabolism.
CC {ECO:0000256|ARBA:ARBA00005074}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate
CC acyltransferase family. {ECO:0000256|ARBA:ARBA00008655}.
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DR EMBL; LWLT01000017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452DYB5; -.
DR Ensembl; ENSCHIT00000012165.1; ENSCHIP00000004672.1; ENSCHIG00000008758.1.
DR GeneTree; ENSGT01030000234574; -.
DR UniPathway; UPA00085; -.
DR Proteomes; UP000291000; Chromosome 20.
DR Bgee; ENSCHIG00000008758; Expressed in thymus and 18 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006644; P:phospholipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd07991; LPLAT_LPCAT1-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR045252; LPCAT1-like.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR23063:SF57; LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 1; 1.
DR PANTHER; PTHR23063; PHOSPHOLIPID ACYLTRANSFERASE; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 374..409
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 445..480
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 58472 MW; 4F316264FB179932 CRC64;
MRLRGRDPRA APSSSAGAGD ARLQAPPGRN PFVHELRLGA LQKAQVAVLT LTLFPVRLLV
VVLMMLLAWP LALVSSLGPA GQEPEQPPAL WRRVVDLLLK AIMRTMWLAG GFHHVVVKGR
QAPPTEAAIL TLAPHSSYFD AIPVTMTMSS VVMKAESRDI PIWGTLIKYI RPVFVSRTDQ
DSRRKTVEEI KRRAQSGGKW PQIMIFPEGT CTNRTCLITF KPGAFIPGVP VQPVVLRYPN
KLVSVFSHAL KILWLTLCQL HNQVEIEFLP VYTPSEEEKK DPALYASNVR QVMAEALGVA
VTDYTFEDCQ LALAEGQLRL PADTCLLEFA RLLRGLGLKP ERLEQDLERH AERARMTQGR
GVTLPEFAVQ LGVPESESLE DLFSLFDEGG GGEVDLREYV VALSVVCRPA RTLDTIQLAF
KMFGSQDGSV EEHALSSILK TALGVAELTV THLFRAIDQE RKGRITFADF EKFVQANPDF
AEEYLYPEQT RPRSCARTPP APTPNGFCAD FSPESSATGT EPVRKKLD
//
