ID   A0A452DZM7_CAPHI        Unreviewed;       412 AA.
AC   A0A452DZM7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Double C2-like domain-containing protein {ECO:0000256|PIRNR:PIRNR036931};
GN   Name=DOC2B {ECO:0000313|Ensembl:ENSCHIP00000005106.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000005106.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000005106.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000005106.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; LWLT01000022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017919865.1; XM_018064376.1.
DR   AlphaFoldDB; A0A452DZM7; -.
DR   STRING; 9925.ENSCHIP00000005106; -.
DR   Ensembl; ENSCHIT00000012697.1; ENSCHIP00000005106.1; ENSCHIG00000009205.1.
DR   GeneID; 102174060; -.
DR   KEGG; chx:102174060; -.
DR   CTD; 8447; -.
DR   GeneTree; ENSGT00940000156758; -.
DR   OMA; HCTINRA; -.
DR   OrthoDB; 590187at2759; -.
DR   Proteomes; UP000291000; Chromosome 19.
DR   Bgee; ENSCHIG00000009205; Expressed in cerebellum and 16 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR   GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR   GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IEA:Ensembl.
DR   GO; GO:0099502; P:calcium-dependent activation of synaptic vesicle fusion; IEA:Ensembl.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR   GO; GO:0061669; P:spontaneous neurotransmitter secretion; IEA:Ensembl.
DR   CDD; cd04035; C2A_Rabphilin_Doc2; 1.
DR   CDD; cd08384; C2B_Rabphilin_Doc2; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR014638; Doc2.
DR   InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR   InterPro; IPR047022; Rabphilin_Doc2_C2A.
DR   InterPro; IPR001565; Synaptotagmin.
DR   PANTHER; PTHR45729:SF9; DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN BETA; 1.
DR   PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR   Pfam; PF00168; C2; 2.
DR   PIRSF; PIRSF036931; Doc2; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   PRINTS; PR00399; SYNAPTOTAGMN.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   PROSITE; PS50004; C2; 2.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          126..250
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          266..399
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          38..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..57
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  45896 MW;  827E1862F8E78754 CRC64;
     MTLRRRGEKA TISIQEHMAI DVCPGPIRPI KQISDYFPRF PRGLPPDAGP RAAAPPDTPA
     RPAAASAGRR SPSDGARDDD EDVDQLFGAY GASPGPGPAP SPGRPPAKPL EEEPDADGYE
     SDDCTALGTL DFSLLYDQEN NALHCTIAKA KGLKPMDHNG LADPYVKLHL LPGASKANKL
     RTKTLRNTLN PTWNETLTYY GITDEDMIRK TLRISVCDED KFRHNEFIGE TRVPLKKLKP
     NHTKTFSICL EKQLPVDKTE DKSLEERGRI LVSLKYSSQK QGLLVGIVRC AHLAAMDANG
     YSDPYVKIYL KPDVDKKSKH KTAVKKKTLN PEFNEEFCYE IKHGDLAKKT LEITVWDYDI
     GKSNDFIGGV VLGINAKGER LKHWFDCLKN KDKRIERWHT LTNELPGAVL SD
//