ID A0A452E039_CAPHI Unreviewed; 394 AA.
AC A0A452E039;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=N-terminal EF-hand calcium binding protein 2 {ECO:0000313|Ensembl:ENSCHIP00000005377.1};
GN Name=NECAB2 {ECO:0000313|Ensembl:ENSCHIP00000005377.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000005377.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000005377.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000005377.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017917264.1; XM_018061775.1.
DR AlphaFoldDB; A0A452E039; -.
DR STRING; 9925.ENSCHIP00000005377; -.
DR Ensembl; ENSCHIT00000013046.1; ENSCHIP00000005377.1; ENSCHIG00000009472.1.
DR GeneID; 102181417; -.
DR KEGG; chx:102181417; -.
DR CTD; 54550; -.
DR GeneTree; ENSGT00950000183131; -.
DR OMA; ARHYPSK; -.
DR OrthoDB; 2900383at2759; -.
DR Proteomes; UP000291000; Chromosome 18.
DR Bgee; ENSCHIG00000009472; Expressed in prefrontal cortex and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0031687; F:A2A adenosine receptor binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031802; F:type 5 metabotropic glutamate receptor binding; IEA:Ensembl.
DR GO; GO:1904021; P:negative regulation of G protein-coupled receptor internalization; IEA:Ensembl.
DR GO; GO:0060168; P:positive regulation of adenosine receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:1900451; P:positive regulation of glutamate receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1905477; P:positive regulation of protein localization to membrane; IEA:Ensembl.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR007138; ABM_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039862; NECAB1/2/3.
DR PANTHER; PTHR12178; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12178:SF2; N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 2; 1.
DR Pfam; PF03992; ABM; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51725; ABM; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 68..103
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 104..137
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 294..382
FT /note="ABM"
FT /evidence="ECO:0000259|PROSITE:PS51725"
FT REGION 41..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 44028 MW; 8344E1D50BFF7433 CRC64;
MCERAARLCR AGAHRLLREP PPQGRALGGL LRWVGARMGE PRAPLAPDAP NTPVADPGPY
PGPASPRGGT AVILDIFRRA DKNDDGKLSL EEFQLFFADG VLNERELEDL FHTIDSDNTN
HVDTKELCDY FVDHMGDYED VLASLETLNH SVLKAMGYTK KVYEGGSNVD QFVTRFLLKE
TANQIQSLLS SVESAVEAIE EQTSQIRQNH SRPRHSAVES WSGSPTPLYA PNHKLMAAEE
GKSFPPGTSD PKEDGLDAQI SRLAGLIGRL ENKTLWFDLQ QHLSDEEGTN MHLQLVRQEM
AVCPEQLGDF LDSLRQYMRG TAGTRNCFHI AAVRLADGVT FVVYEFWETE EEWKRHLQSP
VCKAFRHVKV DMLSQPEAFS RISVPAAWCT LGRD
//
