ID A0A452E086_CAPHI Unreviewed; 185 AA.
AC A0A452E086;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Intraflagellar transport protein 22 homolog {ECO:0000256|ARBA:ARBA00040799};
DE AltName: Full=Rab-like protein 5 {ECO:0000256|ARBA:ARBA00041562};
GN Name=IFT22 {ECO:0000313|Ensembl:ENSCHIP00000005321.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000005321.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000005321.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000005321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase-like component of the intraflagellar transport
CC (IFT) complex B. {ECO:0000256|ARBA:ARBA00037285}.
CC -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80,
CC IFT81, and IFT88. Interacts with IFT88.
CC {ECO:0000256|ARBA:ARBA00038816}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017896524.1; XM_018041035.1.
DR AlphaFoldDB; A0A452E086; -.
DR STRING; 9925.ENSCHIP00000005321; -.
DR Ensembl; ENSCHIT00000012972.1; ENSCHIP00000005321.1; ENSCHIG00000009395.1.
DR GeneID; 102177299; -.
DR KEGG; chx:102177299; -.
DR CTD; 64792; -.
DR GeneTree; ENSGT00390000013187; -.
DR OMA; WYSMFIS; -.
DR OrthoDB; 1326777at2759; -.
DR Proteomes; UP000291000; Chromosome 25.
DR Bgee; ENSCHIG00000009395; Expressed in fallopian tube and 16 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24073; DRAB5-RELATED; 1.
DR PANTHER; PTHR24073:SF528; INTRAFLAGELLAR TRANSPORT PROTEIN 22 HOMOLOG; 1.
DR Pfam; PF08477; Roc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
SQ SEQUENCE 185 AA; 20886 MW; 023568071DBCF71D CRC64;
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYNPTQGVRI LEFENPHVTS NNKGTGCEFE
LWDCGGDPKF ESCWPALMKD SHGVVIVFNA DIPSHLKEIE TWYSCFVQQQ FLQNTQCLLI
AHHKPGSGSD KENPALAPPL NKLKLVHSNL EDDPEEIRME FIKYLRSIIN SVSESRDREE
MSIIT
//
