GenomeNet

Database: UniProt
Entry: A0A452E0K6_CAPHI
LinkDB: A0A452E0K6_CAPHI
Original site: A0A452E0K6_CAPHI 
ID   A0A452E0K6_CAPHI        Unreviewed;      1109 AA.
AC   A0A452E0K6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE            EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN   Name=ATP11C {ECO:0000313|Ensembl:ENSCHIP00000005610.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000005610.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000005610.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC         phospholipidSide 2.; EC=7.6.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00034036,
CC         ECO:0000256|RuleBase:RU362033};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC       ECO:0000256|RuleBase:RU362033}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_017899694.1; XM_018044205.1.
DR   AlphaFoldDB; A0A452E0K6; -.
DR   Ensembl; ENSCHIT00000013305.1; ENSCHIP00000005610.1; ENSCHIG00000009648.1.
DR   GeneID; 102175374; -.
DR   CTD; 286410; -.
DR   GeneTree; ENSGT00940000158878; -.
DR   OrthoDB; 275833at2759; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   Bgee; ENSCHIG00000009648; Expressed in liver and 17 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR   CDD; cd02073; P-type_ATPase_APLT_Dnf-like; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006539; P-type_ATPase_IV.
DR   InterPro; IPR032631; P-type_ATPase_N.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR032630; P_typ_ATPase_c.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 3.
DR   PANTHER; PTHR24092:SF38; PHOSPHOLIPID-TRANSPORTING ATPASE IG; 1.
DR   PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF16212; PhoLip_ATPase_C; 2.
DR   Pfam; PF16209; PhoLip_ATPase_N; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362033};
KW   Magnesium {ECO:0000256|RuleBase:RU362033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362033}.
FT   TRANSMEM        64..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        290..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        344..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        885..906
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        936..958
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        970..992
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1004..1028
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1034..1058
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   DOMAIN          36..91
FT                   /note="P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16209"
FT   DOMAIN          843..880
FT                   /note="P-type ATPase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16212"
FT   DOMAIN          881..1069
FT                   /note="P-type ATPase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16212"
SQ   SEQUENCE   1109 AA;  127225 MW;  C295FBC2F90E27C6 CRC64;
     MFRRSFNRFC AGEEKRVGTR TVFVGNHPVS ETEAYIAQKF CDNRIISSKY TLWNFLPKNL
     FEQFRRIANF YFLIIFLIQV TVDTPTSPIT SGLPLFFVIT VTAIKQGYED WLRHRADNEV
     NKSTVYIIEN AKRVKKESEK IKVGDIVEVQ ADETFPCDLI LLSSCTVDGT CYVTTASLDG
     ESNCKTHYAV RDTIELRTVE SIDNLRAAIE CEQPQSDLYK FVGRINIYSN SLEAVARSLG
     PENLLLKGAT LKNTKKIYGV AVYTGMETKM ALNYQGKSQK RSAVEKSINA FLIVYLFILL
     TKAAICTTLK YVWQSTPYND EPWYNQKTQK ERETWKVLKM FTDFLSFMVL FNFIIPVSMY
     VTVEMQKFLG SFFISWDNDF YDEEINEGAL VNTSDLNEEL GQVDYVFTDK TGTLTENSME
     FIECCIDGHK YKGVAQETDG LSQTDGPLPY LDRADKNREE LFLRALCLCH TVEVKPNDTV
     DGVTESSELT YMSSSPDEIA LVKGAKKYGF TFVGVQNGYM RVENQRKEIE EYELLHTLNF
     DSVRRRMSVI VKTQSGDILL FCKGADSAVF PRVQNHEIDL IKVHVEHNAM EGYRTLCIAF
     KEIAPDDYER VNRQLIEAKM ALQDREEKME KVFDEIETDM HLIGATAVED KLQDQAAETI
     EALHAAGLKV WVLTGDKMET AKSTCYACRL FQTNTELLEL TTKTIEESER KEDRLHELLT
     EYRKKLLREF PKSTRSLKKA WTEHQEYGLI IDGSTLSLIL NSSQDSGSNN YKSIFLQICM
     KCTAVLCCRM APLQKAQIVR MVKNLKGSPI TLSIGDGAND VSMILESHVG IGIKGKEGRQ
     ASRNSDYAVP KFKHLKKLLL AHGHLYYVRI AHLVQYFFYK PLYDAAYLTM YNICFTSLPI
     LAYSLLEQHI NIDTLTSDPR LYMKISGNAM LQLGPFLYWT FLAAFEGTVF FFGTYFLFQT
     TSLDENGKVY GNWTFGTIIF TILVFTVTLK LALDTRFWTW INHLVIWGSL AFYVFFSFFW
     GGIIWPFLKQ QRMYFIFAQM LSSVSIWLTI ILLIFVSLSP EMLRIVLRSV RRRSTRSNLS
     CKKASDSLST RPSVRPLLLR TFSDESNIF
//
DBGET integrated database retrieval system