GenomeNet

Database: UniProt
Entry: A0A452E277_CAPHI
LinkDB: A0A452E277_CAPHI
Original site: A0A452E277_CAPHI 
ID   A0A452E277_CAPHI        Unreviewed;       536 AA.
AC   A0A452E277;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=SNW domain-containing protein 1 {ECO:0000256|RuleBase:RU367140};
GN   Name=SNW1 {ECO:0000313|Ensembl:ENSCHIP00000006117.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000006117.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000006117.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000006117.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in pre-mRNA splicing.
CC       {ECO:0000256|RuleBase:RU367140}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC       {ECO:0000256|RuleBase:RU367140}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367140}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000256|ARBA:ARBA00010197,
CC       ECO:0000256|RuleBase:RU367140}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005686224.1; XM_005686167.2.
DR   AlphaFoldDB; A0A452E277; -.
DR   STRING; 9925.ENSCHIP00000006117; -.
DR   Ensembl; ENSCHIT00000013828.1; ENSCHIP00000006117.1; ENSCHIG00000009978.1.
DR   GeneID; 102172728; -.
DR   KEGG; chx:102172728; -.
DR   CTD; 22938; -.
DR   GeneTree; ENSGT00390000010423; -.
DR   OMA; YGQRRGW; -.
DR   OrthoDB; 5490078at2759; -.
DR   Proteomes; UP000291000; Chromosome 10.
DR   Bgee; ENSCHIG00000009978; Expressed in thymus and 16 other cell types or tissues.
DR   GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR   GO; GO:0050681; F:nuclear androgen receptor binding; IEA:Ensembl.
DR   GO; GO:0042974; F:nuclear retinoic acid receptor binding; IEA:Ensembl.
DR   GO; GO:0042809; F:nuclear vitamin D receptor binding; IEA:Ensembl.
DR   GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0043923; P:positive regulation by host of viral transcription; IEA:Ensembl.
DR   GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070564; P:positive regulation of vitamin D receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0048385; P:regulation of retinoic acid receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; NUCLEAR PROTEIN SKIP-RELATED; 1.
DR   PANTHER; PTHR12096:SF0; SNW DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|RuleBase:RU367140};
KW   mRNA splicing {ECO:0000256|RuleBase:RU367140};
KW   Nucleus {ECO:0000256|RuleBase:RU367140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Spliceosome {ECO:0000256|RuleBase:RU367140}.
FT   DOMAIN          175..335
FT                   /note="SKI-interacting protein SKIP SNW"
FT                   /evidence="ECO:0000259|Pfam:PF02731"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..530
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  61538 MW;  460849D99240E62E CRC64;
     MALTSFLPAP TQLSQDQLEA EEKARSQRSR QTSLVSSRRE PPPYGYRKGW IPRLLEDFGD
     GGAFPEIHVA QYPLDMGRKK KMSNALAIQV DAEGKIKYDA IARQGQSKDK VIYSKYTDLV
     PKEVMNADDP DLQRPDEEAI KEITEKTRVA LEKSVSQKVA AAMPVRAADK LAPAQYIRYT
     PSQQGVAFNS GAKQRVIRMV EMQKDPMEPP RFKINKKIPR GPPSPPAPVM HSPSRKMTVK
     EQQEWKIPPC ISNWKNAKGY TIPLDKRLAA DGRGLQTVHI NENFAKLAEA LYIADRKARE
     AVEMRAQVER KMAQKEKEKH EEKLREMAQK ARERRAGIKT HVEKEDGEAR ERDEIRHDRR
     KERQHDRNLS RAAPDKRSKL QRNENRDISE VIALGVPNPR TSNEVQYDQR LFNQSKGMDS
     GFGCGEDEIY NVYDQAWRGG KDMAQNIYRP SKNLDKDMYG DDLEARIKTN RFVPDKEFSG
     SDRRQRGREG PVQFEEDPFG LDKFLEEAKQ HGGSKRPSDS SRPKEHEHEG KKRRKE
//
DBGET integrated database retrieval system