ID A0A452E2M0_CAPHI Unreviewed; 1194 AA.
AC A0A452E2M0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Partner and localizer of BRCA2 {ECO:0000313|Ensembl:ENSCHIP00000006272.1};
GN Name=PALB2 {ECO:0000313|Ensembl:ENSCHIP00000006272.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000006272.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000006272.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000006272.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005697663.2; XM_005697606.3.
DR AlphaFoldDB; A0A452E2M0; -.
DR STRING; 9925.ENSCHIP00000006272; -.
DR Ensembl; ENSCHIT00000013986.1; ENSCHIP00000006272.1; ENSCHIG00000010148.1.
DR GeneID; 102171120; -.
DR KEGG; chx:102171120; -.
DR CTD; 79728; -.
DR GeneTree; ENSGT00390000014423; -.
DR OMA; GHCQKED; -.
DR OrthoDB; 5404130at2759; -.
DR Proteomes; UP000291000; Chromosome 25.
DR Bgee; ENSCHIG00000010148; Expressed in testis and 18 other cell types or tissues.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR042417; PALB2.
DR InterPro; IPR031920; PALB2_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14662; PARTNER AND LOCALIZER OF BRCA2; 1.
DR PANTHER; PTHR14662:SF2; PARTNER AND LOCALIZER OF BRCA2; 1.
DR Pfam; PF16756; PALB2_WD40; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 850..1193
FT /note="Partner and localiser of BRCA2 WD40"
FT /evidence="ECO:0000259|Pfam:PF16756"
FT REGION 55..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..50
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 66..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1194 AA; 131820 MW; B1AF5892857F9004 CRC64;
MLFLLAAGQM EEPPGKTLSC EEKEKLKEKL AFLKREYTKT LARLQRARRA EKFKNSLRRT
AEEQDSSLQQ EVSTQLTHTE PKNTVSPHDT LQISTHVDEE TGEKTPSSLD IEPLLFSSGH
VSVERSCIQG SDDNQKHFPF RVNRPDAKKR QRKLLGRRKK EERTYISQER EPLSDTDSLI
LSGKRLKEQE KINRENPKIP VTELRTYLLS SPKCAIPNSP APVTETNVGS VLILPSTKPQ
RDVDALLRGN DFPRATTLPL PTPSDSSSGQ LLEHKRPQSN CELTTHSLRN ISSASPVNLQ
VQKKKMTVST DNPEVNKAGS ISGQAARSPN LGADNSCFIN ELTCDNLVEN ENQNLKEQNH
TEMSLKSSND ALGGRNESLL EKEVLSQSKN LSLGVISPVS TEDQIHSCTM LEGLLFPAEY
YVRTTRRMSS CQRKVALEAV IQSHLGVRKK GFKNMSTKSA KKFNVSNEKT KQSEIKVSDT
HADQPSSGSP QKLLSLTEVS FSTDSTEDDF SRKTVTKPSG KKCRGKRKSA CTSPLDHHEL
LLPTSGTSGV KKSKEEIALH RDQNEKAVIH SKKRVKGKEG LCQKEDSLSY SNYAYFSSDD
DAFSTPSHKN KMLSSKHLSS FLKITDFQLP DEDFGFLKLE KLKSCSEKQM EPFGSKVHGE
GHLKGESYIV VEEPSPKQSN IEKEGMEEEL TTLPGKTHSR MPSQRSQPRG KDLSSSILLF
TPLNSVASDD NDRLTADLCS PAFPILGATP AFGSQAHKEK VSAEAGGQTC SPLRLSHLKA
TVSLPSSRKQ CNSWSSPPRL DSSQHVAGRA GQPSCDPDSG PQATTLPTES FTFEASQLQG
SQRHSAEQTE IEVPAWDSLN PGTLQLVSKL KNPSGSCSVD VSATWWEIAG FKEPCIVTAC
EYVVSLWKPL DAWQWEKIYS WHFTEVPVLQ IVAVPDVCNL VCVALGNLEI REIRALLCSP
DGKSEKQVLL SSGNIKAVLG LAKRRLVSSS GTLCDQQVEI MTFAEDGGSK EKQLLMPPEE
TILTFAEVQG MQEALLGTTI MNNIVIWNLK TGQLLKKMHI DDSYQASVCH KAYSEMGLLF
VVLSHPCAKE NELLGSPVFQ LIVINPKTTL SMGVMLYCLP HGQAGRFLEG DVKDHFAAAI
LTSGTIAVWD LLLGHCTALL PPVSGQNWSF VKWSGTDSHL LAGQKDGNIF VYRY
//
