ID A0A452E3E3_CAPHI Unreviewed; 3454 AA.
AC A0A452E3E3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Assembly factor for spindle microtubules {ECO:0000313|Ensembl:ENSCHIP00000006530.1};
GN Name=ASPM {ECO:0000313|Ensembl:ENSCHIP00000006530.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000006530.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000006530.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000006530.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; LWLT01000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000014256.1; ENSCHIP00000006530.1; ENSCHIG00000009909.1.
DR GeneTree; ENSGT00560000077332; -.
DR Proteomes; UP000291000; Chromosome 16.
DR Bgee; ENSCHIG00000009909; Expressed in thymus and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 33.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 41.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 64.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 16.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 44.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 914..1050
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1104..1255
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 528..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3454 AA; 404871 MW; 6593977B57CDA2AA CRC64;
MATWQRGRGC WERSPGPRAE EEAASPAVLS LSHFCRSPFL CFGDVRLGAS RTLPLTLDNP
NEEAAAVRLS RGPAAERGFT IWPSAFVLQP KEKIVVSITW TPLKGGRVRE TVTFLVNDIL
KHQAILLGNA EEPKKKKRTL WDTINKKKVS ASSRHNKKVS NIQNVNKTFN VSPKADKVRS
PLQACENLAT NGNCSPPESN PLILEENKLP ISPISPAFQE CHRETCLPLH VRRSTAYTSL
PASENGELEK ADGANTAKDF HFNEKGITET SFDSIDNVNS QTEESGKLTL TPNYSSSLNI
TQSQGHFLSP DSFVNNSHAS NNEPEFVKCL SPDMFVKGNT RPVLLESKRV HEICRKILSP
DSFINDNYGL NEDLETESVN PILSPNQFLK DNIAYICISQ QTCQLPLSTR RFQDSQPPQD
KRKNAAVPGI SECQQLESPK ATFEASKALE VMSNSYTFKK ENQPKFSAVQ DISSHSREKP
IKRRPILSAT VTKRKPTCAV ENQMETVKPK AKRCLNVVVG DCEKETDDQK EKDDFHPFLP
TRDLIPSRPK SSKNIVTPPC KAASVARKRK SERHTGDENV RVRVTECSEM QEVKRTHFSP
VASKTSTVKH THKVLTSSLK RVSHREKVNL KRKTDSLGYR TPTSKTNKRT RPFVPVAQSN
LTFIKALKAG IPRHPMPFAA KNIFYDERWK EKQEQGFTWW LNFILTPDDF TVKTNISEVN
ASTLLLGVES QRKISVPKAP TKDEVSLRAY TARCRLNRLR RAACRLFTSE KMVKAMKKLE
IEIEARRLIV RKDRHLWKDV GERQKVLNWL LSYNPLWLRI GLETIYGELV PLEDNSDVTG
LAMFILNRLL WNPDIAAEYR HPSVPHLYRD GHEEALSKFT LKKLLLLVCF LDYAKISRLI
DHDPCLFCKD AEFKASKDIL LAFSRDFLGG EGDLSRHLSL LGFPVTHVQM PFDEFDFAVK
NLAVDLQCGV RLVRTMELLT QNWNLSKKLR IPAISRLQKM YNVDIVLEIL KSRGIQLNDE
HGNAILSKDI VDRHREKTLA LLWKIALAFQ VDISLNLDQL KEEIDFLKKT QSMKKTMSAL
LCRPDAVISK KRDERHSGPF EQYSESVKLL MDWVNAVCGF YNKRVENFTV SFSDGRVLCY
LIHHYHPCYV PFDAICQRTT QTVECTHTGS VVLNSSSESD GSFLDLSLKS PDQENTSELY
KELLENEKKN FQLVRSAARD LGGIPAMIHH SDMSNTIPDE KVVITYLSFL CARLLDLRKE
TRAARLIQIT WRQYKLKKDL KHHQERDKAA RIIQSAVINF LTKQRFKKKV SAALVIQKYW
RRALAKRKLL MLKKEKLERV HSKSASIIQR YWRRYSTRKQ FLKLKYYSII LQSKIRMIIA
VASYKRYHWA TVTIQRRWRA HVRSKQDRQR YELLRSSTLV IQSAFRRWRR RKRQSQINAA
ITLQRAFREW RVRKRAQEER AAVVIQSWYR MHRESQKYIH LRSCVIIIQA RFRCFQAQKL
YTRTRESILT LQKHYRAYVK GKVERTGYLQ KRAAAIRLQA AFRGRRARNL CKQIRAACVL
QSYWRMRQDR LRFLNLKKNI IRLQAHIRRR QQLQTYQKMK KAALVIQIHF RAYISAKEVL
ASYQKTRSAV IVLQSACRRM QARKKFLHIL TAVVKIQSYY RAYASRKQFL RLKKATVKLQ
SIVRMKQARK QYLHLRAIAQ QREEHLRASC IKLQAFLRGY LVRKQVRLQR KATVSLQSYF
RMRKMRLDYL KVCQAAVVIQ RYYRAHRAGA QQRKHFLQVR RAVTCLQAAY RGYKVRRQLQ
QQSAAALKIQ AAFRGYRQRT KYQSMLQSAL KIQRWYRTRK MVSAVRSHFF KTRTAAISLQ
SAYRGWKVRK QMRKEHEAAV KIQSAFRTAR AQKEFRLLKT AASVIQQHLR ARAAGLRQRT
EYMALRRAAV TLQSAWRGRA ARRRIQKQQR CAIIIQAYYR RHVQRKRWEI MKKAARLIQM
HYRAYRTGRK QHHLFLKTKG AAIILQSAFR GVRARKKVKE MHQAATTIQS RYRAYQARKK
YASYRAAAVI IQRWYRAAKL AGRQREEYLA VKKAALKIQA VYRGVRERRQ TRRMHTAATL
IKAAFKMQQS RRRYQQMRTA AIVIQVRYRA YRQGRAQRAK YLTTLKAVAL LQAALRGARV
RQNLRRMRTA ATLIQAHYRG RRQQAYFNKL KKVTKTVQQK YRAGRERHAQ LRRYNQLRRS
AVCIQAAFRG MRARKRLKAM HSAAAVIQRR FRTLVMRRRF LSLRKTAVWV QRKYRAKVCA
RHHLQQLRLQ KAAIKIQSWY RGWMVRKKTQ EMRRAATVLQ AAFRRHRARA RYQAWRRASQ
VIQQRFRAGR AARLQRRQYL QQRRSALVLQ AAFRGMRIRK CLKRMHASAT LIQSRFRSVM
MRKRFLSLKK AAVFVQRKYR ATICAKHHLQ RFLELKKAII IIQAFYRRRM VKKQLQEMHR
AAALIQASFR MHRARLAFQT WKLAAILIQQ RYRAYRAAKL QRALYIRWRH SAVVIQAAYK
GLKARQLLRE KHRAAVIIQS TYRMYRQHFS YQKLQWATKV IQERYRVSKR KALQHDALKA
AACARADFQD MVIRRLIQER RHQAAITVQK HFRAFKTRKH YLHFRAKVVF VQRRYRVLMA
VRTQAAICIQ SCFRGFKARR GIQRMHLAAT RIQSCYRRHQ ARADYQAKKR AVVVIQNHYR
SYVRVKMERK KFVAIQKSAR TIQAAFRGMK VRQKLKTMPD EKMAAPATQP AFYCHGTESQ
HEAGQSPALV AQGLHKTSLA GPSQETEHHS QRKAAVAIQK AFHKMVTRRL EKQRRAAVQI
QSFLQMAVYR RRFLQQKRAA LTLQRYFRTQ QSRKRFLLYR EAAVGLQNPH RVFLPAKHQR
ELYLQIRSSV IIIQARVKGF IQKRKFRKLK DSTIKIQAVW RRHKARKYLR EVKAACRIQA
WYRCWKARKE YLAVLRAVRI IQRCFCTQQQ RRRFLNVRAS AVIIQRRWRA VLSGRTTHEQ
SLMTKRHQAA CLIQANFRGY KARQVFLQQK SAALTIQRFI RARKAGKHQR MKYVELKNST
VVLQALVRGW LVRKRISEQR AKIRLLHFAA AAFYHLSALR IQRAYRRHMA LKNANNKQLN
SAICIQRWFR ARSQRKRFLQ KYSIVNIQHE AREQASQHSR AASVIQRAVR RFLLRKKQEN
LNKRIAKIQA LWRGYSWRKK NDTSKTKAIR QRLQCVNREI REENKLYHRT VVALHHLLTY
KYLSTVLEAL KHLEAVTRLS SICCEKMAQS GAISKVFVLI RSCNRSVPCM EVIRYAVQVL
LNVAKYDKTT SAIYDVENCV DTLLELLQMY QEKSGDKVAD KSRSIFTKTC CLLAVLLKTT
TRASDVQSRS KVVDRIYSLY KLTAHKHKVN TDRILCKQKK NSSVSLSFFP ETPVRTRMVS
RLKPDWVLRR DNVEEIMTPL KAIQMVMDTL SLPY
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