ID   A0A452E4C7_CAPHI        Unreviewed;       604 AA.
AC   A0A452E4C7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 7 {ECO:0000313|Ensembl:ENSCHIP00000006849.1};
GN   Name=ENTPD7 {ECO:0000313|Ensembl:ENSCHIP00000006849.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000006849.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000006849.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000006849.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   EMBL; LWLT01000025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005698375.1; XM_005698318.3.
DR   AlphaFoldDB; A0A452E4C7; -.
DR   STRING; 9925.ENSCHIP00000006849; -.
DR   Ensembl; ENSCHIT00000014582.1; ENSCHIP00000006849.1; ENSCHIG00000010544.1.
DR   GeneID; 102178879; -.
DR   KEGG; chx:102178879; -.
DR   CTD; 57089; -.
DR   GeneTree; ENSGT01100000263540; -.
DR   OMA; LNCATKQ; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000291000; Chromosome 26.
DR   Bgee; ENSCHIG00000010544; Expressed in liver and 18 other cell types or tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043273; F:CTPase activity; IEA:Ensembl.
DR   GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR   GO; GO:0006254; P:CTP catabolic process; IEA:Ensembl.
DR   GO; GO:0046039; P:GTP metabolic process; IEA:Ensembl.
DR   GO; GO:0034656; P:nucleobase-containing small molecule catabolic process; IEA:Ensembl.
DR   GO; GO:0050776; P:regulation of immune response; IEA:Ensembl.
DR   GO; GO:0072539; P:T-helper 17 cell differentiation; IEA:Ensembl.
DR   GO; GO:0046052; P:UTP catabolic process; IEA:Ensembl.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF37; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        552..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        217
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         261..265
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   604 AA;  68889 MW;  1AB4AA2AEC39D998 CRC64;
     MARISFSFLC PASWYFTVPT VSPFPRQRVA FLGLFFISCL LLLMLIMDFR HWGASSPRDR
     QYERYLARVG DLEATDTEDP DLNYGLVVDC GSSGSRIFVY FWPRHNGNPH DLLDIKQMRD
     RNSQPVVKKI KPGISAMADT PEHASDYLRP LLSFAAAHVP VRKHKETPLY ILCTAGMRLL
     PERKQLAILA DLVKDLPLEF DFLFSQSQAE VISGKQEGVY AWIGINFVLG RFDHEDEADA
     EAPQELVTGR RRTVGILDMG GASLQIAYEV PTSTSVLSPQ EEEAAKILLA EFNLGCDVQH
     TEHVYRVYVT TFLGFGGNFA RQRYEDLVLN ETLNKNRLLG HKTGLSPDNP FLDPCLPVGL
     TDVVERNSQV LHVRGRGDWA ACGAMLSPLL ARSNTSQASL NGIYQSPIDF NNSEFYGFSE
     FFYCTEDVLR IGGRYHGPTF AKAAQDYCGM AWSVLTQRFK NGLFSSHADE HRLKYQCFKS
     AWMYQVLHEG FHFPYDYPNL QTAQLVYDRE VQWTLGAILY KTRFLPLRDL RQEGVRQAHG
     NWFRLSFVYN HYLFFACILV VLLAIILYLL RLRRIHHRQT RASAPMNLLW IEEVVPMIGV
     QVGP
//