ID A0A452E4Q1_CAPHI Unreviewed; 367 AA.
AC A0A452E4Q1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Left-right determination factor {ECO:0000256|PIRNR:PIRNR037402};
GN Name=LOC102183990 {ECO:0000313|Ensembl:ENSCHIP00000006969.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000006969.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000006969.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000006969.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037402}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037402,
CC ECO:0000256|RuleBase:RU000354}.
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DR EMBL; LWLT01000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017915468.1; XM_018059979.1.
DR AlphaFoldDB; A0A452E4Q1; -.
DR STRING; 9925.ENSCHIP00000006969; -.
DR Ensembl; ENSCHIT00000014705.1; ENSCHIP00000006969.1; ENSCHIG00000010623.1.
DR GeneID; 102183990; -.
DR KEGG; chx:102183990; -.
DR GeneTree; ENSGT00390000010056; -.
DR OMA; VSVYWVQ; -.
DR OrthoDB; 5391376at2759; -.
DR Proteomes; UP000291000; Chromosome 16.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR003942; LRDF.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PIRSF; PIRSF037402; TGFb4; 1.
DR PRINTS; PR01427; TGFBETA4.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Cytokine {ECO:0000256|PIRNR:PIRNR037402};
KW Developmental protein {ECO:0000256|PIRNR:PIRNR037402};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037402};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037402};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..367
FT /note="Left-right determination factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019167680"
FT DOMAIN 241..355
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 367 AA; 41543 MW; 3A49A6D6D2291922 CRC64;
MRPLWLCWAL WVLPLTGHGA ALTEEWILDS LLQQLHLSEV PIVDKAAVEG LVIPAHVRAQ
YVALLQRSHG ARSRGKRFSQ NFREVVGRFL ESEVSSYLLV FDMEQRLPPR SELVQAVLRL
FQEPVPKAAL RRHERLFPRS DRARVTVQWL HVRDDGSNRT ALIDSRLVSI HESGWKALDV
TEAVNFWQQL RSPRQPLLLQ VLVQREHLGP LASSAHRLVR FAPQGPSSGR QGEPQLELHT
LDLRDYGAQG NCDPKAPVTE GTRCCRQEMY IDLRGMRWAE NWVLEPPGFL AYECVGTCQQ
PPESLTFKWP FLGPRQCIAS ETTSLPMIVS IQEGGRLQPQ VVSLPNMRVQ TCSCASDGAL
VPRKLEP
//
