ID A0A452E532_CAPHI Unreviewed; 587 AA.
AC A0A452E532;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Transcription factor 7 like 1 {ECO:0000313|Ensembl:ENSCHIP00000007165.1};
GN Name=TCF7L1 {ECO:0000313|Ensembl:ENSCHIP00000007165.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000007165.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000007165.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000007165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR EMBL; LWLT01000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017910876.1; XM_018055387.1.
DR AlphaFoldDB; A0A452E532; -.
DR STRING; 9925.ENSCHIP00000007165; -.
DR Ensembl; ENSCHIT00000014905.1; ENSCHIP00000007165.1; ENSCHIG00000010768.1.
DR GeneID; 102187776; -.
DR KEGG; chx:102187776; -.
DR CTD; 83439; -.
DR GeneTree; ENSGT00940000157038; -.
DR OMA; HPLSWLV; -.
DR OrthoDB; 5351131at2759; -.
DR Proteomes; UP000291000; Chromosome 11.
DR Bgee; ENSCHIG00000010768; Expressed in metanephros cortex and 16 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF25; TRANSCRIPTION FACTOR 7-LIKE 1; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 344..412
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 344..412
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 62567 MW; 0063FF082B17A231 CRC64;
MPQLGGGGGG GSGGGSGGSG AGAAGGGDDL GANDELIPFQ DEGGEEQEPS SDSASAQRDL
DEVKSSLVNE SENQSSSSDS EAERRPQPAR DAFQKPRDYF AEVRRPQDGA FFKGPPYPGY
PFLMIPDLSS PYLPNGPLSP GGARTYLQMK WPLLDVPAST TVKDARSPSP AHLSNKVPVV
QHPHHMHPLT PLITYSNDHF SPGSPPTHLS PEIDPKTGIP RPPHPSELSP YYPLSPGAVG
QIPHPLSWLV PQQGQPMYSL PPGGFRHPYP ALAMNASMSS LVSSRFSPHM VAPAHPGLPT
SGIPHPAIVS PIVKQEPAPP SLSPAVSAKS PVTVKKEEEK KPHVKKPLNA FMLYMKEMRA
KVVAECTLKE SAAINQILGR KWHNLSREEQ AKYYELARKE RQLHSQLYPT WSARDNYGKK
KKRKREKQLS QTQSQQQQVQ EADGALASKS KKPCVQYLPP EKPCDSPASS HGSMLDSPAT
PSAALASPAA PAATHSEQAQ PLSLTTKPET RAQLALHSAA FLSSKAAATS SGQMGSQPPL
LSRPLPLGSV PTALLTSPPS FPATLHAHQA LPVLQAQPLS LVTKSAH
//
