ID A0A452E6A6_CAPHI Unreviewed; 439 AA.
AC A0A452E6A6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=General transcription factor IIE subunit 1 {ECO:0000313|Ensembl:ENSCHIP00000007532.1};
GN Name=GTF2E1 {ECO:0000313|Ensembl:ENSCHIP00000007532.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000007532.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000007532.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000007532.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TFIIE alpha subunit family.
CC {ECO:0000256|ARBA:ARBA00008947}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452E6A6; -.
DR STRING; 9925.ENSCHIP00000007532; -.
DR Ensembl; ENSCHIT00000015276.1; ENSCHIP00000007532.1; ENSCHIG00000010996.1.
DR GeneTree; ENSGT00390000016696; -.
DR OMA; DAIKWKV; -.
DR Proteomes; UP000291000; Chromosome 1.
DR Bgee; ENSCHIG00000010996; Expressed in spleen and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR Gene3D; 6.10.140.1250; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039997; TFE.
DR InterPro; IPR017919; TFIIE/TFIIEa_HTH.
DR InterPro; IPR002853; TFIIE_asu.
DR InterPro; IPR021600; TFIIE_asu_C.
DR InterPro; IPR024550; TFIIEa/SarR/Rpc3_HTH_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR13097:SF8; GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1; 1.
DR PANTHER; PTHR13097; TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF11521; TFIIE-A_C; 1.
DR Pfam; PF02002; TFIIE_alpha; 1.
DR SMART; SM00531; TFIIE; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51344; HTH_TFE_IIE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 14..104
FT /note="HTH TFE/IIEalpha-type"
FT /evidence="ECO:0000259|PROSITE:PS51344"
FT REGION 331..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49402 MW; 1F522CAAD58706D5 CRC64;
MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN PCVKEEDMLE LLKFDRKQLR
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCQTE VEEDESAMPK KDARTLLARF
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDR AASAAGAAGL AGGHHREAWT
TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY SSEEMKEGGI
DIDSFQEHEE GHAGPDDNEE VMRALLIHEK KTPSAPAGSV GAAAPMTAAN GSDSESETSE
SDDDSPPRVA TVAAHHGEED EEDDEFEEVA DDPIVMVAGR PFSYSEVSQK PELVAQMTPE
EKEAYIAMGQ RMFEDLFEW
//
