ID A0A452E9S7_CAPHI Unreviewed; 909 AA.
AC A0A452E9S7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Calcium-activated chloride channel regulator 1 {ECO:0000256|ARBA:ARBA00041120};
GN Name=CLCA1 {ECO:0000313|Ensembl:ENSCHIP00000008637.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000008637.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000008637.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000008637.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the CLCR family.
CC {ECO:0000256|ARBA:ARBA00006398}.
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DR EMBL; LWLT01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005678208.2; XM_005678151.3.
DR AlphaFoldDB; A0A452E9S7; -.
DR STRING; 9925.ENSCHIP00000008637; -.
DR Ensembl; ENSCHIT00000016399.1; ENSCHIP00000008637.1; ENSCHIG00000011719.1.
DR GeneID; 102186450; -.
DR KEGG; chx:102186450; -.
DR CTD; 1179; -.
DR GeneTree; ENSGT00940000154682; -.
DR OMA; QERVFVH; -.
DR OrthoDB; 5479609at2759; -.
DR Proteomes; UP000291000; Chromosome 3.
DR Bgee; ENSCHIG00000011719; Expressed in descending colon and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR004727; CLCA_chordata.
DR InterPro; IPR013642; CLCA_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR NCBIfam; NF041940; choice_anch_X; 1.
DR NCBIfam; TIGR00868; hCaCC; 1.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF52; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1; 1.
DR Pfam; PF08434; CLCA; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00023049};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..909
FT /note="Calcium-activated chloride channel regulator 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019441719"
FT DOMAIN 306..475
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 909 AA; 99920 MW; 523845FF69E35E2F CRC64;
MGSFKNSVFI LVLHLLEGAL SDSLIQLNNN GYEGIVIAID PNVPEDETLI QHIKDMVTDA
SPYLFEATEK RFYFKNVAIL IPENWKTKPE YVKPKLETYK NADVLVAEPN PTGNDGPYTE
QMGGCGEKGD RIYLTPDFLA GNKLLQYGPQ GRAFVHEWAH LRWGVFNEYN NDQKFYLSNR
RKKPVICSAG ITGETVIEKC QGGSCVTQPC KHDRKTGLYE EGCEFIPHKS QTEKASIMYS
QSIDTVVKFC TEKNHNKEAP NQQNTKCNRR STWEVIQDSE DFKTTTPMTT QPPKPTFSLL
QIGQRIVCLV LDKSGSMTIG NRLKRLNQAG KLFLLQTVEQ GSWVGMVTFD SAAYVQSELV
QINSATERDT LTKSLPTTAS GGTSICSGLQ SAFTVIKKKY PTDGAEIVLL TDGEDNTISA
CFDEVKQSGA IIHTVALGPS AAQELEEMSK MTGGLQTYAS DQVQNNGLMD AFAALSSGNK
AVSQRSIQLE SRGLTLQNSQ WMNGTVTVDS TVGKDTLFLI TWTTDLPQIL LWDPSGNKQD
GFVVDTNTKM AYLQIPDIAK IGIWKYSLQA SSQTLTLTVT SRASSATLPP VTVTSKVNKD
TGKFPSPMVV YVKIHQGTKP ILRAKVTALI ESVDGKTATL ELLDNGAGAD ATKGDGIYSR
YFTAYDTNGR YSVKVWALGG VNTASQTVSA QQNGAMYIPG WIENGEVKWN PPRPAINKDQ
GKQVCFSRTS SGGSFVATDV PKAPIPDLFP PCKITDLKAE IQGDELINLT WTAPGDDYDH
GRADKYIIRI STNILELRDK FNESLQVNTT DLIPKEANSE EVFVFKPETI TFTNGTDLFI
AIQAVDKVSL KSEISNIAQV SLFIPPEIPP EKPSPSLPCP DININSTIPG IHILKIMWKW
LGELQISLG
//
