ID A0A452EAZ8_CAPHI Unreviewed; 357 AA.
AC A0A452EAZ8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
GN Name=NDRG2 {ECO:0000313|Ensembl:ENSCHIP00000009183.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000009183.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000009183.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000009183.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC Down-regulates CTNNB1-mediated transcriptional activation of target
CC genes. May be involved in neuron differentiation.
CC {ECO:0000256|RuleBase:RU367129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU367129}.
CC -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC ECO:0000256|RuleBase:RU367129}.
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DR EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017910009.1; XM_018054520.1.
DR RefSeq; XP_017910011.1; XM_018054522.1.
DR RefSeq; XP_017910012.1; XM_018054523.1.
DR RefSeq; XP_017910013.1; XM_018054524.1.
DR AlphaFoldDB; A0A452EAZ8; -.
DR SMR; A0A452EAZ8; -.
DR Ensembl; ENSCHIT00000016954.1; ENSCHIP00000009183.1; ENSCHIG00000012099.1.
DR GeneID; 102171430; -.
DR CTD; 57447; -.
DR GeneTree; ENSGT00950000182872; -.
DR OMA; KTCFQPL; -.
DR OrthoDB; 5352016at2759; -.
DR Proteomes; UP000291000; Chromosome 10.
DR Bgee; ENSCHIG00000012099; Expressed in cerebellum and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367129};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU367129};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU367129};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU367129}.
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 39208 MW; 9F255C18E283F0C4 CRC64;
MAELREVQIT EEKPLLPGQT PEVAKTHSVE TPYGSVTFTV YGTPKPKRPA ILTYHDVGLN
YKSCFQPLFQ FADMQEIIQN FVRVHVDAPG MEEGAPVFPL GYQYPSLDQL ADMIPCILQY
LNFSTIIGIG VGAGAYVLSR YALTHPDTVE GLVLINIDPN AKGWMDWAAH KLTGLTSSIS
EMILGHLFSQ EELSGNSELI QKYRNIIAHA PNLDNIELYW NSYNNRRDLN FVRGGDTTLK
CPVMLVVGDQ APHEDAVVEC NSKLDPTQTS FLKMADSGGQ PQLTQPGKLT EAFKYFLQGM
GYMASSCMTR LSRSRTASLT SAASIDGNRS RSRTLSQSSE SGTLSSGPPG HTMEVSC
//
