ID A0A452EBW5_CAPHI Unreviewed; 1024 AA.
AC A0A452EBW5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NLR family CARD domain-containing protein 4 {ECO:0000256|ARBA:ARBA00015338};
DE AltName: Full=Ice protease-activating factor {ECO:0000256|ARBA:ARBA00030378};
GN Name=NLRC4 {ECO:0000313|Ensembl:ENSCHIP00000009511.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000009511.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000009511.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000009511.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EBW5; -.
DR STRING; 9925.ENSCHIP00000009511; -.
DR Ensembl; ENSCHIT00000017284.1; ENSCHIP00000009511.1; ENSCHIG00000012340.1.
DR GeneTree; ENSGT00940000161744; -.
DR OMA; KDWYHTP; -.
DR Proteomes; UP000291000; Chromosome 11.
DR Bgee; ENSCHIG00000012340; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0089720; F:caspase binding; IEA:Ensembl.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0016045; P:detection of bacterium; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0010954; P:positive regulation of protein processing; IEA:Ensembl.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.1900.50; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR042220; NLRC4.
DR InterPro; IPR040535; NLRC4_HD.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47688; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR47688:SF1; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17889; NLRC4_HD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..88
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 163..252
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1024 AA; 116032 MW; 07E3B7E5EDEB5C17 CRC64;
VNFIKENSQV LIQRMGMTVI KQILDELFVW NVMNYEEVSV ILGERFEQDA ARGIIHMILK
KGSEACNLFL KSLEKRNYPL FQELHGLSKY QFMSEDDLDD LAQELKYFYE SPSFLNFYPL
GEDIDIMFNL KSTFTEPVLW KKDQHHHRLE QLTLSGLLDT LQSPCIIEGE SGKGKSTLLQ
RIAMLWASGE CQALAKFKLV FFLRLSRAQG GLFKTLSDQL LDIPDVISKQ TFMATLLKLR
QRVLFLLDGY NEFKAQNCPE IEALIKENHR FKNMVIVTTT TESLRHIRQF GALIAEVGDM
TESSAQALIQ EVLRKEFAEG LLLQIQKSRC LRNLMKTPLF VVITCAIQMG KSEFHSHTQT
TLFCAFYDLL INKNRHKRKG LAPSEVTQSL DHCGDLALEG VFSRRFDFEP DDLSDVNEDV
LLTTGLLCKY TAQRFKPKYK FFHQSFQEYT AGRRLSSLLT SGEPAEVTKG NGHLQKMVSI
SDITSKYSNL LLYTCGSSAE ATRTVLRHLS SVYEHGSLLG LSVTKRPLWR QESMQNMKST
TVQEIQKAIN INSFTECGIN LFHESISTSS LSNEFEAFFR GKSLYINSEN IPDYLFDFFE
DLPNCASALD FVKLDFYGGT VASWDKTTED IGRTQDQEFS GTYIPSRAVS LFFNGKQEFK
TLEVTLRDFC KLSKKDVKYL EKIFSSATSL RLHIKRCVGM AGSLSSVLST CTKIHSLIVE
ASPLTLEDEQ HITSVTNLQT LGVHDLQIQR LPGGLTDSLG NLKNLTKLIL DNIKMNEDDA
LKLAEGLTNL KKMCLLRLTH LSDIGEGMDY IVKTLSAEPC DLKEIQLVSC CLSGNAVKTL
AQNLHNLAKL SILDLSENHL EKDGKEALRQ LIDRLHILEQ LTVLMLPWCG DVRVSQARLL
EQLKKVPQLV KLGLKNWRLT DAEIRILGVF FEENPLENFQ QLDLAGNCVS SDGWLAFMSG
FENLKQLVFF DFSTKALLPD ASLVRKLSHV LSKLTFLQEV QLVGWQLDDD DVSVLKGAFQ
LVIA
//
