ID A0A452EDS1_CAPHI Unreviewed; 3013 AA.
AC A0A452EDS1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Bromodomain PHD finger transcription factor {ECO:0000313|Ensembl:ENSCHIP00000010172.1};
GN Name=BPTF {ECO:0000313|Ensembl:ENSCHIP00000010172.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000010172.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000010172.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000010172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9925.ENSCHIP00000010172; -.
DR Ensembl; ENSCHIT00000017945.1; ENSCHIP00000010172.1; ENSCHIG00000012772.1.
DR GeneTree; ENSGT00940000154830; -.
DR OMA; PEQYTNV; -.
DR Proteomes; UP000291000; Chromosome 19.
DR Bgee; ENSCHIG00000012772; Expressed in thymus and 17 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016589; C:NURF complex; IEA:Ensembl.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 2.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 247..307
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 397..444
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2845..2896
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2922..2992
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1418..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1982..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2240..2277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2353..2536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2697..2716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2775..2836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2031..2058
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2602..2635
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..36
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..194
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1462..1480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1637..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2353..2375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2376..2400
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2401..2526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2697..2712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2776..2800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2812..2836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3013 AA; 333687 MW; 627CEBCA7E2450EC CRC64;
MRGRRGRPPK QPAAPAAERC APAPPPPPPP PPTSGPIGGL RSRHRGSSRG RWAAAQAEVA
PKTRLSSPRG GSSSRRKPPP PPPPPPAPPS TSAPGRGGRG GGGGRTGGGG GGGHLARTTP
ARRAVNKVVY DDHESEEEEE EEDMVSEEEE EEEEDGDAEE TQDSEDDEED EMEEDDDDSD
YPEEMEDDDD DDASYCTESS FRSHSTYSST PGRRKPRVHR PRSPILEEKD IPPLEFPKSS
EDLMVPNEHI MNVIAIYEVL RNFGTVLRLS PFRFEDFCAA LVSQEQCTLM AEMHVVLLKA
VLREEDTSNT TFGPADLKDS VNSTLYFIDG MTWPEVLRVY CESDKEYHHV LPYQEAEDYP
YGPVENKIKV LQFLVDQFLT TNIAREELMS EGVIQYDDHC RVCHKLGDLL CCETCSAVYH
LECVKPPLEE VPEDEWQCEV CVAHKVPGVT DCVAEIQKNK PYIRHEPIGY DRSRRKYWFL
NRRLIIEEDT ENEDEKKIWY YSTKVQLAEL IDCLDKDYWE AELCKILEEM REEIHRHMDI
TEDLTNKARG SNKSFLAAAN EEILESIRAK KGDIDIVKSP EEIDKDKNET ENSNSKDAEK
SREEFEDQIV EKDSDDKTPD DVDPEQGRSE EPTEVGDKGN SVSANLGDNT TNASSEETVP
SEGRSPMGCV SETHDSSNMA EKKVASELPQ DVPEEPNKTC DSSNTSAPTT CIQPNLELSN
SSSELSSSQS EPAKAADDPE NGEREPHTPV SIQEEIGDFK SEKSNGEISE SPGGGRGASG
STRIITRLRN PDSKLSQLKS QQVAAAAHEA NKLFKEGKEV LVVNSQGEIS RLSTKKEVVM
KGNINNYFKL GQEGKYRVYH NQYSTNSFAL NKHQHREDHD KRRHLAHKFC LTPAGEFKWN
GSVHGSKVLT ISTLRLTITQ LENNIPSSFL HPNWASHRAN WIKAVQMCSK PREFALALAI
LECAVKPVVM LPIWRESLGH TRLHRMTSIE REEKEKVKKK EKKQEEEETM QQATWVKYTF
PVKHQVWKQK GEEYRVTGYG GWSWISKTHV YRFVPKLPGN TNVHYRKPVE GVKNNMDENM
DESDRRKSPR SPKKIKTEPD SEKGEVKDSD AAKGADQSEM DISKVTEKKD QDVKEVLDSD
NDKSFKEEPM EIDDDMKTES HVNCQESSQV DVVNVSEGFH LRTSYKKKIK SSKLDGLLER
RIKQFTLEEK QRHEKMKLEG GIKGSGKTPT SSVKSLSESP VITKVKEGCQ SDLLTQEQSS
NSSNDKSEDS IQGCSQSDSS ILGISDPDHT ANKLYSKDQM LEDVSIQSAE THCQKQNSVQ
NDMDEGLSDP ANEGQEPSKI KTKGTDFLID DSKLASADEI GTLIYKNRKP FIQEDNDTTV
CPSQSPLLPS VPKSTDDRDI PSLSKAIVFE GKLGCDSEYN STLENSSDTM SVQDSSEEDM
IVQNSNESIS EQLITQEQAS EGFEPLKREF VSDKTTGSCD DRLQGKVNDA NGRKPSQDQK
LEERPLNKCI DQNSLKSVTD KKNNENRESE KKGQKASTFQ INGKDNKAKV YLKGECLRDI
SESKIGSGDI EPKVNNINKI IPENDIKPLT VKESTVKPFM NGDVIMEDFN EKNNLETKSR
LLRSSDAEGG YHGSLETLPS TRESESAQAT MPLPSCPEGS SSNQVEDMEI DTSKVKKVTS
SPVTSGEESN LSNDFIDENG LPTNKDENVN GEPKRKTVIT EVTTMTSTVA TESKTVIKVA
KGDKQTVVSA TENCAKSTVT TTTTTVTKLS TPSAGSDVDI ISVKEQSKTV VTTTVTDSLT
TAGGTLVTSM TVSKEYSTRD KVKLMKFSRP KKTRSGTALP SYRKFITKSS KKSIFVLPND
DLKKLARKGG IREVPYFNYN AKPALDIWPY PSPRPTFGIT WRYRLQTVKS LAGVSLMLRL
LWASLRWDDM AAKAPPGGGT TRTETSETEI TTTEIIKRRD VGPYGIRSEY CIRKIICPIG
VPEAPKETPT PQRKGLRSSA LRPKRPETPK QTGPVIIETW VAEEELELWE IRAFAERVEK
EKAQAVEQQA KKRLEQQKPT VIAASTTSPT NSTTSTISPA QKVMVAPISG SVTAGTKMVL
TTKVGSPATV TFQQNKNFHQ TFATWVKQGQ SNSGVVQVQQ KVLGIIPSST GTSQQTFTSF
QPRTATVTIR PNTSGSGGTT TASQVITGPQ IRPGMTVIRT PLQQSTLGKA IIRTPVMVQP
GAPQQVVTQI IRGQPVSTAI SAPSTVSSTP AQKGLSSGTS TASLQPSASQ PPRPQQGQVK
LTMAQLTQLT QGHGGNQGLT VVIQGQGQTT GQLQLIPQGV TILPGPGQQL MQAAMPNGTV
QRFLFTPLAT TAATTSATTT TVSTTAAEAQ PQPAQPAQPS AQPSAQPQPQ TQPPSPAQPE
TQTQPEVQTQ TAVASHVPPE AQPTQAQSSK AQVAGQCPPQ SNGQGQPPAR VQSPPQTRAR
PSTPSQVSPG QQAQGQTAAS QPIPIQPHTS LPTPSQGQPQ SQPQVQSSTQ TLSPGQTLSQ
VTVASPPRPP LQVPQPQPQV LAVPQLPPQV QVLSQIQSQV VAQIQAQQGG VPQQIRLQLP
VQIQQSSPVQ THHIQSVVTV QAASVQEQLQ RVQQLREQQQ KKKQQQIEME REHTLQASNQ
SEIIQKQVVM KHNAVIEHLK QKKTMTPAER EENQRMIVCN QVMKYILDKI DKEEKQAAKK
RKREESVEQK RSKQNASKLS ALLFKHKEQL KAEILKKRAL LDKDLQIEVQ EELKRDLKIK
KEKDLVQATA VAATCPAAPP APPAPPPSPP PPPPPQHPGP LATATTTLPV ASQKRKREEE
RDSNSKSKKK KMISTTSKET KKDTKLYCIC KTPYDESKFY IGCDRCQNWY HGRCVGILQS
EAELIDEYVC PQCQSTEDAM TVLTPLTEKD YEGLKRVLRS LQAHKMAWPF LEPVDPNDAP
DYYGVIKEPM DLATMEERVQ RRYYEKLTEF VADMTKIFDN CRYYNPSDSP FYQCAEVLES
FFVQKLKGFK ASR
//
