ID A0A452EEE3_CAPHI Unreviewed; 564 AA.
AC A0A452EEE3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=GP-PDE domain-containing protein {ECO:0000259|PROSITE:PS51704};
GN Name=LOC102183041 {ECO:0000313|Ensembl:ENSCHIP00000010434.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000010434.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000010434.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000010434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00007277}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EEE3; -.
DR Ensembl; ENSCHIT00000018213.1; ENSCHIP00000010434.1; ENSCHIG00000012938.1.
DR GeneTree; ENSGT00940000156251; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Bgee; ENSCHIG00000012938; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR PANTHER; PTHR23344:SF13; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR Pfam; PF03009; GDPD; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..502
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
SQ SEQUENCE 564 AA; 65844 MW; E6D27C21219DFA7E CRC64;
MPMKANKIEP QSQTRKQKKD TPWILHIFNH KCFVTTIIGC YSCHWKIRQE KKFKHGQCCS
LRERLFYPYL VISFCMSVLL VFVWVESSNE YNGFDWVIFI GTGLWFFWSI VLLSFLGILA
AYTSLLLVLG ILLLWEGIEL YLHWCHKVFA PYIHLSSIAM MVILSWPLAF YLIHLEGEAR
IRRYQMTCNE RKRNKRCNVL TKLRALQVAI GLPFFLILLC LYLLPLGNFS PCVQEKNKLA
PKPDFFGHRG APMLGPENTI MSFEKAVEHG AYGLESDVHI SYDHVPFLMH DSDLRRTTNI
KEVLPDASLT HPSLFDWDFL STLNAGKWFS HAPIKPFFGM KPLSKADRER AGNQKIPKLT
ELLELAQKEK KFVIFDLNGP APNHSLRALY VRHVVSIILD SQIEQHLIFW LPNFEREYVK
KKAPGFQQVG RLLPVERLTK ENITRINADY KNLFYNGMRE YRAANISINL YLVNEPWLFS
LAWCSRIPSV TTDNIQVLNE MTQPSYFMTP KYYLLVWILM DILSAVFIVA IFYFHWWKES
KQEKFLKSTS IHTGTLFFAV TPSQ
//
