ID A0A452EEZ3_CAPHI Unreviewed; 689 AA.
AC A0A452EEZ3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Solute carrier family 22 member 23 {ECO:0000313|Ensembl:ENSCHIP00000010575.1};
GN Name=SLC22A23 {ECO:0000313|Ensembl:ENSCHIP00000010575.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000010575.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000010575.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000010575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LWLT01000028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017894291.1; XM_018038802.1.
DR RefSeq; XP_017894292.1; XM_018038803.1.
DR AlphaFoldDB; A0A452EEZ3; -.
DR STRING; 9925.ENSCHIP00000010575; -.
DR Ensembl; ENSCHIT00000018354.1; ENSCHIP00000010575.1; ENSCHIG00000013035.1.
DR GeneID; 102178125; -.
DR KEGG; chx:102178125; -.
DR CTD; 63027; -.
DR GeneTree; ENSGT00940000157354; -.
DR OrthoDB; 5321340at2759; -.
DR Proteomes; UP000291000; Chromosome 23.
DR Bgee; ENSCHIG00000013035; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17444; MFS_SLC22A23; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF192; SOLUTE CARRIER FAMILY 22 MEMBER 23; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..625
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 73487 MW; 57E4333B7D8F1D45 CRC64;
MAIDRRREAA GGGPGRLPPA AEENGALPPG DAAASAPLGG RAGPGGGGDI QPLPAPHAAG
GPHPSLLLLD YDGSVLPFLG GLGGGYQKTL VLLTWIPALF IGFSQFSDSF LLDQPNFWCR
GAGKGAESAG VTATGRWDGG DLANGTSPPT TLFPAAPWGT AGPLGNGNGS GADGGEAPPL
PSPPDKGDNA SNCDCHAWDY GIRTGLVQNV VSKWDLVCDN AWKVHVAKFS LLVGLIFGYL
ITGCVADWFG RRPVLLFSII FILIFGLTVA LSVNVTMFST LRFFEGFCLA GVTLTLYALR
IELCPPGKRF MITMVASFVT TAGQFLMPGL AALCRDWQVL QALIICPFLL TLLYWSIFPE
SLRWLMATHQ FESAKKLILH FTQKNHMNPE SDIKGVMPEL EKELSRRPRK VCIVKVVGTR
NLWKNIVVLC VNSLTGFGIH HCFARSMMGH EVKVPLLEDF YADYYAAAGI ALASCLAMCL
AVRVLGRRGG LLLFMILTAL ASLLQLGLLN LIGKYSQHPD SELQLKLAVG MSDSVKDKFS
IAFSIVGMFA SHAVGSLSVF FCAEITPTVI RCGGLGLVLA SAGFGMLTAP IIELHNQKGY
FLHHVIFACC TLICIICLLL LPESRGQSLP ESIPDGEHYT RQPLLPPRRG EQPLLPTHAE
LKDYSGLHDA AAAGDGLPDG ATANGGRPM
//
