ID   A0A452EGF0_CAPHI        Unreviewed;       881 AA.
AC   A0A452EGF0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Exocyst complex component 2 {ECO:0000256|ARBA:ARBA00017526, ECO:0000256|RuleBase:RU365069};
GN   Name=EXOC2 {ECO:0000313|Ensembl:ENSCHIP00000011112.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000011112.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000011112.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000011112.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000256|ARBA:ARBA00002660, ECO:0000256|RuleBase:RU365069}.
CC   -!- SUBUNIT: Component of the exocyst complex.
CC       {ECO:0000256|RuleBase:RU365069}.
CC   -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000256|ARBA:ARBA00010578,
CC       ECO:0000256|RuleBase:RU365069}.
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DR   EMBL; LWLT01000028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A452EGF0; -.
DR   Ensembl; ENSCHIT00000018898.1; ENSCHIP00000011112.1; ENSCHIG00000013305.1.
DR   GeneTree; ENSGT00390000010872; -.
DR   Proteomes; UP000291000; Chromosome 23.
DR   Bgee; ENSCHIG00000013305; Expressed in descending colon and 17 other cell types or tissues.
DR   GO; GO:0000145; C:exocyst; IEA:UniProtKB-UniRule.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR029175; EXOC2/Sec5.
DR   InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   PANTHER; PTHR13043:SF1; EXOCYST COMPLEX COMPONENT 2; 1.
DR   PANTHER; PTHR13043; EXOCYST COMPLEX COMPONENT SEC5; 1.
DR   Pfam; PF15469; Sec5; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   3: Inferred from homology;
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|RuleBase:RU365069};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365069}.
FT   DOMAIN          8..91
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|Pfam:PF01833"
FT   DOMAIN          133..841
FT                   /note="Exocyst complex component EXOC2/Sec5 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15469"
SQ   SEQUENCE   881 AA;  98088 MW;  5100B9F782FA1FF4 CRC64;
     MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPADLIG LTICGHNCLL TAEWMSASKI
     VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLRPEKIGI LDQSAVWVDE MNYYDMRTDR
     NKGIPPLSLR PANPLGIEIE KGKFPQKDLE TLFPGMSADF TSENFSAAWY LIENHSSASF
     EQLKMAIAHL KRQANKKSEG SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ
     KLENVLNRAS NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNTQKGDYD
     VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL EKLLETPSTL HDQKRYIRHL
     SDLHAPGDPA WQCIGAQHRW ILQLMHSCRE GCVRDLKGPP GLHGTSLDLD AELRASAPSH
     LGQTASLKRG SSFQPGRDDA WRCKTPHRVA FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS
     ETAEKSGHIE RSKNVRQRQN DFKKMIQEVM QCLVKLVRGA LLPLGAAEGG GRQHGGWEAK
     AELPGQWLAH TIQTLRLTYD SLAALEIPSD LLQTIQDLVL DLRVRCVVVT LQHTAEDIKR
     LAEKEDWVVD SEGLTSLPCR FERCVLLSLQ SLRGVLECKP GEASVSVGGR LPGRGHPGFL
     YCLEQLSTKP DADVDTAHLS VDVSSPDLFG SIHEDFGLTS EQRLLIVLSN CCYLERYTFL
     NIAEQFEKHN FQGIERITQV SMASLKDLDQ RLFESYIELK ADPIVGSLEP GIYAGYFDWR
     DCLPPTGGWF QVPGLQVHVF TVSKDLVPRV LSRVVEAVSE ELSRLMQCVS SFSRNGALQV
     PCLCCARGPS CLNHGDVCQL QSSFKQALEA LPQLSSGADR K
//