ID   A0A452EI28_CAPHI        Unreviewed;       888 AA.
AC   A0A452EI28;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 4 {ECO:0000313|Ensembl:ENSCHIP00000011556.1};
GN   Name=ITIH4 {ECO:0000313|Ensembl:ENSCHIP00000011556.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000011556.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000011556.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000011556.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   EMBL; LWLT01000024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013829034.2; XM_013973580.2.
DR   AlphaFoldDB; A0A452EI28; -.
DR   SMR; A0A452EI28; -.
DR   Ensembl; ENSCHIT00000019346.1; ENSCHIP00000011556.1; ENSCHIG00000013634.1.
DR   GeneID; 102178021; -.
DR   CTD; 3700; -.
DR   GeneTree; ENSGT00940000161039; -.
DR   OMA; EFIYWIN; -.
DR   OrthoDB; 608326at2759; -.
DR   Proteomes; UP000291000; Chromosome 22.
DR   Bgee; ENSCHIG00000013634; Expressed in liver and 17 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF119; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..888
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019290242"
FT   DOMAIN          20..149
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          275..458
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          596..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..620
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   888 AA;  98769 MW;  281043DDA8527697 CRC64;
     METPAPGRTH SVVLVLLSLA VLHTSKAQKV QNDIDIYSLT VDSKVSSRFA HTVITSRVVN
     KADAVREATF QMELPKKAFI TNFSMVIDGV TYPGNIKEKA AAQEQYSAAM ARGESAGLVT
     ATGRKTEQFQ VSVSVAPAAK VTFELVYEEL LARHLGVYEL LLKVRPQQLV KHLQMDIHIF
     EPEGISFLET ESTFMTNELA EALTTSQNKT KAHVRFKPTL SQQQKSPEKQ DTVLDGNFIV
     RYDVDRPVSG GSIQIENGYF VHYFAPDSLS TMPKNVIFVI DKSGSMMGRK IKQTQEALIK
     ILDDLSPHDQ FNLISFSAEA TKWKPLLVPA STENVNEAKS YATGIRAQGG TNINDAMLMA
     VQLLEKANRE ELLPAGSITL IILLTDGDPT AGETDPLKIQ ENVRKAVNGQ HSLFCLGFGF
     DVSYAFLEKM ALENGGLARR IYEDSDSALQ LQDFYQEVAN PLMMSVAFEY PSNAVESVTQ
     DAFRVFFKGS ELVVAGKLRD HSPDVLSAQV RGQLHGENIT FVMESHVAEQ EEMFRGPKYI
     FHSFMERLWA YLTIQQLLEQ MVSALDAEKQ ALEARALSLS LSYSFVTPLT SMVITKPEGQ
     EQSQVAEKPV EDESRDRRVP LGGGLKLLNS PPRLGVPGRF LAPPPPFYRT TSRLVLPELT
     LRPGGASYDM DFRIKGTTLT APPFAPIQAP SVILPLPGQS VDQLCVDFRR PQELVNLLSD
     PDQGVEVTGH YETAKACFSW IEVTFENPQL QVHASPEHVV ITRNRRNSAY KWKETLYSVM
     PGLKVTMDKA GLLLLSRPDR VTIGLLFWDG PGKGLRLLLQ DTDRFSSHVS GTLGQFYQDV
     LWGPLDTADD RKRTLKVQGR DYSATRELKL DYQESPPGKE ISCWSVEL
//