ID A0A452EIX7_CAPHI Unreviewed; 1303 AA.
AC A0A452EIX7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSCHIP00000011903.1};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSCHIP00000011903.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000011903.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000011903.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000011903.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; LWLT01000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000019693.1; ENSCHIP00000011903.1; ENSCHIG00000013837.1.
DR GeneTree; ENSGT00940000159011; -.
DR OMA; HLYDTEW; -.
DR Proteomes; UP000291000; Chromosome 8.
DR Bgee; ENSCHIG00000013837; Expressed in cerebellum and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 373..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1055..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1087..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 372..532
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1122..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1303 AA; 146062 MW; 6C0408CF628A1DCF CRC64;
MGKATGRKAP LWLRAKFQRL LFKLGCYIQK NCGKFLVVGL LIFGAFAVGL KAANLETNVE
ELWVEVGGRV SRELNYTRQK IGEEAMFNPQ LMIQTPKEEG ANVLTTEALR QHLDSALQAS
RVHVYMYNRQ WKLEHLCYKS GELITETGYM DQIIEYLYPC LIITPLDCFW EGAKLQSGTA
YLLGKPPLQW TNFDPLEFLE ELKKINYQVD SWEEMLNKAE VGHGYMDRPC LNPADPDCPA
TAPNKNTTKP LDMALVLNGG CHGLSRKYMH WQEELIVGGT VKNSTGKLVS AHALQTMFQL
MTPKQMYEHF KGYEYVSHIN WNEDKAAAIL EAWQRTYVEV VHQSVAQNST QKVLSFTTTT
LDDILKSFSD VSVIRVASGY LLMLAYACLT MLRWDCSKSQ GAVGLAGVLL VALSVAAGLG
LCSLIGISFN AATTQVLPFL ALGVGVDDVF LLAHAFSETG QNKRIPFEDR TGECLKRTGA
SVALTSISNV TAFFMAALIP IPALRAFSLQ AAVVVVFNFA MVLLIFPAIL SMDLYRREDR
RLDIFCCFTS PCVSRVIQVE PQAYTETHDN TRYSPPPPYS SHSFAHETQI TMQSTVQLRT
EYDPHTHVYY TTAEPRSEIS VQPVTMAQDT LSCQSPESTS STRDLLSQFS DSSLHCLEPP
CTRWTLSSFA EKHYAPFLLK PKAKVVVIFL FLGLLGVSLY GTTRVRDGLD LTDIVPRETR
EYDFIAAQFK YFSFYNMYIV TQKADYPNIQ HLLYDLHKSF SNVKYVMLEE NKQLPKMWLH
YFRDWLQGLQ DAFDSDWETG KIMPNNYKNG SDDGVLAYKL LVQTGSRDKP IDISQLTKRR
LVDADGIINP SAFYIYLTAW VSNDPVAYAA SQANIRPHRP EWVHDKADYM PETRLRIPAA
EPIEYAQFPF YLNGLRDTSD FVEAIEKVRT ICNNYTSLGL SSYPNGYPFL FWEQYIGLRH
WLLLSISVVL ACTFLVCAVF LLNPWTAGII VTVLALMTVE LFGMMGLIGI KLSAVPVVIL
IASVGIGVEF TVHVALAFLT AIGDKNRRAV LALEHMFAPV LDGAVSTLLG VLMLAGSEFD
FIVRYFFAVL AILTILGVLN GLVLLPVLLS FFGPYPEVVH PEPRHHPLSN PRQQSHLDSR
TLPPGQPGQQ PRRETPRECL RPPPYKPRRD AFEISTEGHS GPSNRDRTGP RGARSHNPRH
HNPAFTAMGS SMPSYCQPIT TVTASASVTV AVHPPPAPGP GPSRNPRSGL CPGYEDYPET
DHGLFEDPHV PFNVRCERRE PKVEVIELQD VECEERRQGS SSN
//