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Database: UniProt
Entry: A0A452EIX7_CAPHI
LinkDB: A0A452EIX7_CAPHI
Original site: A0A452EIX7_CAPHI 
ID   A0A452EIX7_CAPHI        Unreviewed;      1303 AA.
AC   A0A452EIX7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSCHIP00000011903.1};
GN   Name=PTCH1 {ECO:0000313|Ensembl:ENSCHIP00000011903.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000011903.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000011903.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000011903.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; LWLT01000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCHIT00000019693.1; ENSCHIP00000011903.1; ENSCHIG00000013837.1.
DR   GeneTree; ENSGT00940000159011; -.
DR   OMA; HLYDTEW; -.
DR   Proteomes; UP000291000; Chromosome 8.
DR   Bgee; ENSCHIG00000013837; Expressed in cerebellum and 16 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   InterPro; IPR004766; TM_rcpt_patched.
DR   NCBIfam; TIGR00918; 2A060602; 1.
DR   PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR   PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR   Pfam; PF02460; Patched; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        373..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        404..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        478..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        507..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        685..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        722..740
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        961..982
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        988..1010
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1017..1043
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1055..1075
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1087..1112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          372..532
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          1122..1209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1234..1253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1132..1148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1154..1175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1303 AA;  146062 MW;  6C0408CF628A1DCF CRC64;
     MGKATGRKAP LWLRAKFQRL LFKLGCYIQK NCGKFLVVGL LIFGAFAVGL KAANLETNVE
     ELWVEVGGRV SRELNYTRQK IGEEAMFNPQ LMIQTPKEEG ANVLTTEALR QHLDSALQAS
     RVHVYMYNRQ WKLEHLCYKS GELITETGYM DQIIEYLYPC LIITPLDCFW EGAKLQSGTA
     YLLGKPPLQW TNFDPLEFLE ELKKINYQVD SWEEMLNKAE VGHGYMDRPC LNPADPDCPA
     TAPNKNTTKP LDMALVLNGG CHGLSRKYMH WQEELIVGGT VKNSTGKLVS AHALQTMFQL
     MTPKQMYEHF KGYEYVSHIN WNEDKAAAIL EAWQRTYVEV VHQSVAQNST QKVLSFTTTT
     LDDILKSFSD VSVIRVASGY LLMLAYACLT MLRWDCSKSQ GAVGLAGVLL VALSVAAGLG
     LCSLIGISFN AATTQVLPFL ALGVGVDDVF LLAHAFSETG QNKRIPFEDR TGECLKRTGA
     SVALTSISNV TAFFMAALIP IPALRAFSLQ AAVVVVFNFA MVLLIFPAIL SMDLYRREDR
     RLDIFCCFTS PCVSRVIQVE PQAYTETHDN TRYSPPPPYS SHSFAHETQI TMQSTVQLRT
     EYDPHTHVYY TTAEPRSEIS VQPVTMAQDT LSCQSPESTS STRDLLSQFS DSSLHCLEPP
     CTRWTLSSFA EKHYAPFLLK PKAKVVVIFL FLGLLGVSLY GTTRVRDGLD LTDIVPRETR
     EYDFIAAQFK YFSFYNMYIV TQKADYPNIQ HLLYDLHKSF SNVKYVMLEE NKQLPKMWLH
     YFRDWLQGLQ DAFDSDWETG KIMPNNYKNG SDDGVLAYKL LVQTGSRDKP IDISQLTKRR
     LVDADGIINP SAFYIYLTAW VSNDPVAYAA SQANIRPHRP EWVHDKADYM PETRLRIPAA
     EPIEYAQFPF YLNGLRDTSD FVEAIEKVRT ICNNYTSLGL SSYPNGYPFL FWEQYIGLRH
     WLLLSISVVL ACTFLVCAVF LLNPWTAGII VTVLALMTVE LFGMMGLIGI KLSAVPVVIL
     IASVGIGVEF TVHVALAFLT AIGDKNRRAV LALEHMFAPV LDGAVSTLLG VLMLAGSEFD
     FIVRYFFAVL AILTILGVLN GLVLLPVLLS FFGPYPEVVH PEPRHHPLSN PRQQSHLDSR
     TLPPGQPGQQ PRRETPRECL RPPPYKPRRD AFEISTEGHS GPSNRDRTGP RGARSHNPRH
     HNPAFTAMGS SMPSYCQPIT TVTASASVTV AVHPPPAPGP GPSRNPRSGL CPGYEDYPET
     DHGLFEDPHV PFNVRCERRE PKVEVIELQD VECEERRQGS SSN
//
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